IOCAS-IR
Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants
Li, Xiaomin1,2,3,4; Xing, Ronge1,2,3,4; Xu, Chaojie1,2,3,4; Liu, Song1,2,3; Qin, Yukun1,2,3; Li, Kecheng1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
2021-07-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume264Pages:16
Corresponding AuthorXing, Ronge(xingronge@qdio.ac.cn)
AbstractVaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential.
KeywordChitosan Quaternized chitosan Immunostimulatory activities Immune mechanism Vaccine adjuvant
DOI10.1016/j.carbpol.2021.118050
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0311300] ; Key Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2019YYSP028]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000647409300001
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/170944
Collection中国科学院海洋研究所
Corresponding AuthorXing, Ronge
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xiaomin,Xing, Ronge,Xu, Chaojie,et al. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants[J]. CARBOHYDRATE POLYMERS,2021,264:16.
APA Li, Xiaomin.,Xing, Ronge.,Xu, Chaojie.,Liu, Song.,Qin, Yukun.,...&Li, Pengcheng.(2021).Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.CARBOHYDRATE POLYMERS,264,16.
MLA Li, Xiaomin,et al."Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants".CARBOHYDRATE POLYMERS 264(2021):16.
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