IOCAS-IR
Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants
Li, Xiaomin1,2,3,4; Xing, Ronge1,2,3,4; Xu, Chaojie1,2,3,4; Liu, Song1,2,3; Qin, Yukun1,2,3; Li, Kecheng1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
2021-07-15
发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
卷号264页码:16
通讯作者Xing, Ronge(xingronge@qdio.ac.cn)
摘要Vaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential.
关键词Chitosan Quaternized chitosan Immunostimulatory activities Immune mechanism Vaccine adjuvant
DOI10.1016/j.carbpol.2021.118050
收录类别SCI
语种英语
资助项目National Key R&D Program of China[2018YFC0311300] ; Key Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2019YYSP028]
WOS研究方向Chemistry ; Polymer Science
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号WOS:000647409300001
出版者ELSEVIER SCI LTD
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/170944
专题中国科学院海洋研究所
通讯作者Xing, Ronge
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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GB/T 7714
Li, Xiaomin,Xing, Ronge,Xu, Chaojie,et al. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants[J]. CARBOHYDRATE POLYMERS,2021,264:16.
APA Li, Xiaomin.,Xing, Ronge.,Xu, Chaojie.,Liu, Song.,Qin, Yukun.,...&Li, Pengcheng.(2021).Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.CARBOHYDRATE POLYMERS,264,16.
MLA Li, Xiaomin,et al."Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants".CARBOHYDRATE POLYMERS 264(2021):16.
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