Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury

doi:10.1021/acs.jnatprod.1c00027

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	Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury
	Wu, Jianzhang 1; Xi, Yiyuan 1; Li, Ge 1; Zheng, Yuantie 1; Wang, Zhongle 1; Wang, Jingsong 1; Fang, Chengyan 1; Sun, Zhongmin 2; Hu, Linya 1; Jiang, Wei3 ; Dai, Lishang 1; Dong, Jianyong 1; Qiu, Peihong 1; Zhao, Min 1; Yan, Pengcheng 1
	2021-04-23
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	84 期号:4 页码:1306-1315
通讯作者	Zhao, Min(zhaomin@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn)
摘要	Five new diterpenes, including four new hydroazulenes, (8R,11R)-8, 11- diacetoxypachydictyol A (1), (8R,11R) -6-O-acety1-8- acetoxy-11-hydroxypachydictyol A (2), (8R,11S)-8-acetoxy-11-hydroxypachydictyol A (3), and (8R,11S)-6-O-acety1-8,11-dihydroxypachydictyol A (4), and a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8-acetoxypachydictyol A (5), were isolated from a South China Sea collection of a Dictyota sp. nov. brown alga, together with five known analogues (6-10). Structure elucidation was achieved by extensive spectroscopic analysis and comparison with reported data. All compounds showed potent antioxidant effects against H2O2-induced oxidative damage in neuron-like PC12 cells at a low concentration of 2 mu M. The antioxidant property of dictyol C (9) was associated with activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI.
DOI	10.1021/acs.jnatprod.1c00027
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000644478400038
出版者	AMER CHEMICAL SOC
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/170860
专题	中国科学院海洋研究所
通讯作者	Zhao, Min; Yan, Pengcheng
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Yangzhou Univ, Sch Environm Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jianzhang,Xi, Yiyuan,Li, Ge,et al. Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1306-1315.
APA	Wu, Jianzhang.,Xi, Yiyuan.,Li, Ge.,Zheng, Yuantie.,Wang, Zhongle.,...&Yan, Pengcheng.(2021).Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury.JOURNAL OF NATURAL PRODUCTS,84(4),1306-1315.
MLA	Wu, Jianzhang,et al."Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1306-1315.

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