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Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480
Meng, Ling-Hong1,2; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Wang, Bin-Gui1,2,3
2020-07-01
Source PublicationMARINE DRUGS
Volume18Issue:7Pages:10
Corresponding AuthorMeng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractThe co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (1) and B (2), together with three known sesquiterpenoids, sesquicaranoic acid B (3), cyclonerodiol (4) and bisabol-l-on-13-sauremethylester (5), were characterized from a co-culture of the marine-derived fungal isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound1represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher's method and electronic circular dichroism (ECD) calculations. Compound1showed potent inhibitory activities againstCeratobasidium cornigerumandEdwardsiella tarda.
KeywordPenicillium chermesinum Penicillium bilaiae co-culture secondary metabolites antimicrobial activity
DOI10.3390/md18070339
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[31600267] ; Natural Science Foundation of China[41976090] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000554187500001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/168079
Collection实验海洋生物学重点实验室
Corresponding AuthorMeng, Ling-Hong; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,et al. Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480[J]. MARINE DRUGS,2020,18(7):10.
APA Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,&Wang, Bin-Gui.(2020).Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480.MARINE DRUGS,18(7),10.
MLA Meng, Ling-Hong,et al."Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480".MARINE DRUGS 18.7(2020):10.
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