Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480 | |
Meng, Ling-Hong1,2 ; Li, Xiao-Ming1,2; Li, Hong-Lei1,2; Wang, Bin-Gui1,2,3
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| 2020-07-01 | |
| Source Publication | MARINE DRUGS
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| Volume | 18Issue:7Pages:10 |
| Corresponding Author | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (1) and B (2), together with three known sesquiterpenoids, sesquicaranoic acid B (3), cyclonerodiol (4) and bisabol-l-on-13-sauremethylester (5), were characterized from a co-culture of the marine-derived fungal isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound1represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher's method and electronic circular dichroism (ECD) calculations. Compound1showed potent inhibitory activities againstCeratobasidium cornigerumandEdwardsiella tarda. |
| Keyword | Penicillium chermesinum Penicillium bilaiae co-culture secondary metabolites antimicrobial activity |
| DOI | 10.3390/md18070339 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of China[31600267] ; Natural Science Foundation of China[41976090] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000554187500001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/168079 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Meng, Ling-Hong; Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,et al. Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480[J]. MARINE DRUGS,2020,18(7):10. |
| APA | Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,&Wang, Bin-Gui.(2020).Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480.MARINE DRUGS,18(7),10. |
| MLA | Meng, Ling-Hong,et al."Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480".MARINE DRUGS 18.7(2020):10. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Chermebilaenes A and（895KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View | |
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