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	The cyclic lipopeptides suppress the motility ofVibrio alginolyticusvia targeting the Na+-driven flagellar motor componentMotX
	Liu, Rui1,2,3; Zheng, Rikuan1,2,3,4; Liu, Ge1,2,3; Sun, Chaomin1,2,3
	2020-07-28
发表期刊	ENVIRONMENTAL MICROBIOLOGY
ISSN	1462-2912
页码	14
通讯作者	Sun, Chaomin(sunchaomin@qdio.ac.cn)
摘要	In our previous study, we found that pumilacidin-like cyclic lipopeptides (CLPs) derived from marine bacteriumBacillussp. strain 176 significantly suppressed the mobile capability and virulence ofVibrio alginolyticus. Here, to further disclose the mechanism of CLPs inhibiting the motility ofV.alginolyticus, we first applied transcriptomic analysis toV.alginolyticustreated with or without CLPs. The transcriptomic results showed that the expression of several important components of the Na+-driven flagellar motor closely related to bacterial motility were markedly suppressed, suggesting that the structure and function of Na+-driven flagellar motor might be disabled by CLPs. The transcriptomic data were further analysed by the protein-protein interaction network, and the results supported that MotX, one of the essential components of Na+-driven flagellar motor was most likely the action target of CLPs. In combination of gene knockout, electrophoretic mobility shift assay and immunoblotting techniques, CLPs were demonstrated to affect the rotation of flagella ofVibrio alginolyticusvia direct interacting with the Na+-driven flagellar motor component MotX, which eventually inhibited the bacterial motility. Interestingly, homologues of MotX were found broadly distributed and highly conserved in different pathogenic species, which extends the application range of CLPs as an antibacterial drug targeting bacterial motility in many pathogens.
DOI	10.1111/1462-2920.15144
收录类别	SCI
语种	英语
资助项目	National Key R and D Program of China[2018YFC0310800] ; Young Scientists Fund of LMBB[YQ2018NO02] ; Qingdao National Laboratory for Marine Science and Technology ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050301] ; Taishan Young Scholar Program of Shandong Province[tsqn20161051] ; Qingdao Innovation Leadership Program[18-1-2-7-zhc] ; China Ocean Mineral Resources R&D Association Grant[DY135-B2-14]
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000552750800001
出版者	WILEY
引用统计	被引频次：7[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167988
专题	实验海洋生物学重点实验室
通讯作者	Sun, Chaomin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Rui,Zheng, Rikuan,Liu, Ge,et al. The cyclic lipopeptides suppress the motility ofVibrio alginolyticusvia targeting the Na+-driven flagellar motor componentMotX[J]. ENVIRONMENTAL MICROBIOLOGY,2020:14.
APA	Liu, Rui,Zheng, Rikuan,Liu, Ge,&Sun, Chaomin.(2020).The cyclic lipopeptides suppress the motility ofVibrio alginolyticusvia targeting the Na+-driven flagellar motor componentMotX.ENVIRONMENTAL MICROBIOLOGY,14.
MLA	Liu, Rui,et al."The cyclic lipopeptides suppress the motility ofVibrio alginolyticusvia targeting the Na+-driven flagellar motor componentMotX".ENVIRONMENTAL MICROBIOLOGY (2020):14.

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