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The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei
Wang, Quanchao1,2,3; Yu, Yang1,3,4; Zhang, Qian1,4,5; Luo, Zheng1,4,5; Zhang, Xiaojun1,3,4; Xiang, Jianhai1,4; Li, Fuhua1,3,4,6
2020-08-01
Source PublicationMARINE BIOTECHNOLOGY
ISSN1436-2228
Volume22Issue:4Pages:564-571
AbstractThe Pacific white shrimpLitopenaeus vannameiis one of the major economic aquaculture species. The growth trait is considered as the most important trait inL. vannameiaquaculture. Identification of the genetic components underlying growth-related traits inL. vannameicould be useful for the selective breeding of growth trait. Our previous work identified several growth-related SNPs by genome-wide association study (GWAS). Based on the assembled genome, we identified a new candidate gene (LvMMD2) beside the associated marker. This gene encodes the progestin and AdipoQ receptor 10 (PAQR10) protein. We further investigate the polymorphisms ofLvMMD2and their association with body weight ofL. vannamei. By resequencing the coding region ofLvMMD2, a total of 8 SNPs were identified, including 6 synonymous mutations and 2 nonsynonymous mutations. Association analyses based on a population of 322 individuals revealed that several SNPs located in the coding region ofLvMMD2were significantly associated with the body weight, especially the nonsynonymous mutation named as MMD_5 contributed the most association to the trait and it could explain 10.5% of phenotypic variance. In addition, several genes involved in growth and development have been identified asLvMMD2-interacting genes. These findings strongly suggested thatLvMMD2might be an important gene regulating the shrimp growth. More importantly, the MMD_5 could be a promising candidate locus for marker-assisted selection (MAS) of the body weight inL. vannamei.
KeywordPenaeid shrimp Growth traits GWAS Candidate gene MMD2
DOI10.1007/s10126-020-09977-0
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018 YFD0901301] ; National Key R&D Program of China[2018YFD0900303] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105] ; Agricultural Variety Improvement Project of Shandong Province[2019LZGC014] ; China Agriculture Research System-48
WOS Research AreaBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS SubjectBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:000542504500001
PublisherSPRINGER
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/167796
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Fuhua
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Quanchao,Yu, Yang,Zhang, Qian,et al. The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei[J]. MARINE BIOTECHNOLOGY,2020,22(4):564-571.
APA Wang, Quanchao.,Yu, Yang.,Zhang, Qian.,Luo, Zheng.,Zhang, Xiaojun.,...&Li, Fuhua.(2020).The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei.MARINE BIOTECHNOLOGY,22(4),564-571.
MLA Wang, Quanchao,et al."The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei".MARINE BIOTECHNOLOGY 22.4(2020):564-571.
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