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Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species
Wang, Tianming1,2; Cao, Zheng3; Shen, Zhangfei3; Yang, Jingwen1,2; Chen, Xu1; Yang, Zhen1; Xu, Ke1; Xiang, Xiaowei1; Yu, Qiuhan1; Song, Yimin1; Wang, Weiwei3; Tian, Yanan3; Sun, Lina4; Zhang, Libin4,5; Guo, Su2; Zhou, Naiming3
2020-06-09
Source PublicationELIFE
ISSN2050-084X
Volume9Pages:28
Corresponding AuthorWang, Tianming(wangtianming@zjou.edu.cn) ; Zhou, Naiming(zhounaiming@zju.edu.cn)
AbstractThe kisspeptin system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here, we report the identification and characterization of the kisspeptin system in the sea cucumber Apostichopus japonicus. The gene encoding the kisspeptin precursor generates two mature neuropeptides, AjKiss1a and AjKiss1b. The receptors for these neuropeptides, AjKissR1 and AjKissR2, are strongly activated by synthetic A. japonicus and vertebrate kisspeptins, triggering a rapid intracellular mobilization of Ca2+, followed by receptor internalization. AjKissR1 and AjKissR2 share similar intracellular signaling pathways via G(alpha q)/PLC/PKC/MAPK cascade, when activated by C-terminal decapeptide. The A. japonicus kisspeptin system functions in multiple tissues that are closely related to seasonal reproduction and metabolism. Overall, our findings uncover for the first time the existence and function of the kisspeptin system in a non-chordate species and provide new evidence to support the ancient origin of intracellular signaling and physiological functions that are mediated by this molecular system.
DOI10.7554/eLife.53370
Indexed BySCI
Language英语
Funding ProjectNational Science Foundation of China[41876154] ; National Science Foundation of China[41406137] ; National Science Foundation of China[41606150] ; Center for Ocean Mega-Research of Science, Chinese Acadamy of Science[COMS2019Q15]
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000541447600001
PublisherELIFE SCIENCES PUBLICATIONS LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167766
Collection海洋生态与环境科学重点实验室
Corresponding AuthorWang, Tianming; Zhou, Naiming
Affiliation1.Zhejiang Ocean Univ, Marine Sci Coll, Natl Engn Res Ctr Marine Facil Aquaculture, Zhoushan, Peoples R China
2.Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Programs Human Genet & Biol Sci, San Francisco, CA 94143 USA
3.Zhejiang Univ, Coll Life Sci, Inst Biochem, Zijingang Campus, Hangzhou, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tianming,Cao, Zheng,Shen, Zhangfei,et al. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species[J]. ELIFE,2020,9:28.
APA Wang, Tianming.,Cao, Zheng.,Shen, Zhangfei.,Yang, Jingwen.,Chen, Xu.,...&Zhou, Naiming.(2020).Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species.ELIFE,9,28.
MLA Wang, Tianming,et al."Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species".ELIFE 9(2020):28.
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