Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480 | |
Hu, Xue-Yi1,2,3 ; Li, Xiao-Ming1,2; Yang, Sui-Qun1,2; Liu, Hui1; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,4
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| 2020-04-01 | |
| Source Publication | MARINE DRUGS
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| Volume | 18Issue:4Pages:10 |
| Corresponding Author | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Secondary metabolites obtained from marine-derived fungi are rich sources of drug candidates. Three new sesquiterpenoids, chermesiterpenoids A-C (1-3), along with four known alkaloids (4-7), were isolated and identified from the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of these new sesquiterpenoids were elucidated using detailed analysis of the NMR data and their relative configurations were elucidated using nuclear overhauser effect spectroscopy (NOESY) spectra as well as gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis. Their absolute configurations were determined using electronic circular dichroism (ECD) calculations and modified Mosher's method. Compounds 2 and 3 exhibited potent activities against human and aquatic pathogenic bacteria and plant pathogenic fungi. |
| Keyword | Penicillium chermesinum algal-derived fungus sesquiterpenoid antimicrobial activity |
| DOI | 10.3390/md18040194 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of China[31330009] ; Natural Science Foundation of China[31600267] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Taishan Scholar Project from Shandong Province |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000533909300047 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/167624 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Meng, Ling-Hong; Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Hu, Xue-Yi,Li, Xiao-Ming,Yang, Sui-Qun,et al. Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480[J]. MARINE DRUGS,2020,18(4):10. |
| APA | Hu, Xue-Yi,Li, Xiao-Ming,Yang, Sui-Qun,Liu, Hui,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480.MARINE DRUGS,18(4),10. |
| MLA | Hu, Xue-Yi,et al."Three New Sesquiterpenoids from the Algal-Derived Fungus Penicillium chermesinum EN-480".MARINE DRUGS 18.4(2020):10. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Three New Sesquiterp（3270KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View | |
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