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Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance
Xu, Gangming; Yang, Suiqun
2019-12-01
发表期刊APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
卷号103期号:23-24页码:9373-9378
摘要Bacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ gamma-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with GBL synthase. The pseudo GblR regulators may act as transcriptional repressors and respond to antibiotic signals. They play regulatory roles in coordination of antibiotic biosynthesis by connecting the hormone feed-forward loops and the antibiotic feedback loops. As the TetR family members, they might also have evolutionary roles between the transcriptional regulators of quorum sensing and antibiotic resistance. Understanding the regulatory and evolutionary roles of the pseudo GblR family would be helpful for fine-tuning regulation of antibiotic biosynthesis and resistance.
关键词Microbial hormone gamma-butyrolactone Quorum sensing Antibiotic resistance
DOI10.1007/s00253-019-10219-0
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[31200042] ; National Natural Science Foundation of China[31570038] ; National Natural Science Foundation of China[31570038] ; National Natural Science Foundation of China[31200042]
WOS研究方向Biotechnology & Applied Microbiology
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000509524600014
出版者SPRINGER
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/164422
专题实验海洋生物学重点实验室
通讯作者Xu, Gangming
作者单位Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Xu, Gangming,Yang, Suiqun. Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(23-24):9373-9378.
APA Xu, Gangming,&Yang, Suiqun.(2019).Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(23-24),9373-9378.
MLA Xu, Gangming,et al."Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.23-24(2019):9373-9378.
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