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Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance
Xu, Gangming; Yang, Suiqun
2019-12-01
Source PublicationAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
Volume103Issue:23-24Pages:9373-9378
Corresponding AuthorXu, Gangming(aericxu@gmail.com)
AbstractBacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ gamma-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with GBL synthase. The pseudo GblR regulators may act as transcriptional repressors and respond to antibiotic signals. They play regulatory roles in coordination of antibiotic biosynthesis by connecting the hormone feed-forward loops and the antibiotic feedback loops. As the TetR family members, they might also have evolutionary roles between the transcriptional regulators of quorum sensing and antibiotic resistance. Understanding the regulatory and evolutionary roles of the pseudo GblR family would be helpful for fine-tuning regulation of antibiotic biosynthesis and resistance.
KeywordMicrobial hormone gamma-butyrolactone Quorum sensing Antibiotic resistance
DOI10.1007/s00253-019-10219-0
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31570038] ; National Natural Science Foundation of China[31200042]
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000509524600014
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164422
Collection实验海洋生物学重点实验室
Corresponding AuthorXu, Gangming
AffiliationChinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xu, Gangming,Yang, Suiqun. Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(23-24):9373-9378.
APA Xu, Gangming,&Yang, Suiqun.(2019).Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(23-24),9373-9378.
MLA Xu, Gangming,et al."Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.23-24(2019):9373-9378.
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