Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107 | |
Song, Qi1,2,3; Li, Xiao-Ming1,2,4; Hu, Xue-Yi1,2 ; Li, Xin1,2,4; Chi, Lu-Ping1,2,3; Li, Hong-Lei1,2,4; Wang, Bin-Gui1,2,4
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| 2019-12-01 | |
| Source Publication | PHYTOCHEMISTRY LETTERS
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| ISSN | 1874-3900 |
| Volume | 34Pages:30-34 |
| Corresponding Author | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Six secondary metabolites including a new aminobenzoic peptide seco-clavatustide B (1) and a new clavatoic acid derivative 5-acetyl-2,4-dihydroxy-3-methylbenzoic acid (3), were characterized from the EtOAc extracts of the Ascidian-derived endophytic fungus Aspergillus clavatus AS-107. The absolute configuration of compound 1 was established by electronic circular dichroism quantum calculation and the structure of compound 3 was elucidated on the basis of spectroscopic data together with single-crystal X-ray diffraction experiment. The isolated compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1 and 2 showed potent activity against aquatic pathogens Aeromonas hydrophilia and Pseudomonas aeruginosa with MIC values of 8.2 and 8.8 mu M, respectively. |
| Keyword | Ascidian-derived fungus Aspergillus clavatus Secondary metabolites Antibacterial activity |
| DOI | 10.1016/j.phytol.2019.09.004 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal |
| WOS ID | WOS:000498702200006 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/163808 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Song, Qi,Li, Xiao-Ming,Hu, Xue-Yi,et al. Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107[J]. PHYTOCHEMISTRY LETTERS,2019,34:30-34. |
| APA | Song, Qi.,Li, Xiao-Ming.,Hu, Xue-Yi.,Li, Xin.,Chi, Lu-Ping.,...&Wang, Bin-Gui.(2019).Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107.PHYTOCHEMISTRY LETTERS,34,30-34. |
| MLA | Song, Qi,et al."Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107".PHYTOCHEMISTRY LETTERS 34(2019):30-34. |
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