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Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107
Song, Qi1,2,3; Li, Xiao-Ming1,2,4; Hu, Xue-Yi1,2; Li, Xin1,2,4; Chi, Lu-Ping1,2,3; Li, Hong-Lei1,2,4; Wang, Bin-Gui1,2,4
2019-12-01
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume34Pages:30-34
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractSix secondary metabolites including a new aminobenzoic peptide seco-clavatustide B (1) and a new clavatoic acid derivative 5-acetyl-2,4-dihydroxy-3-methylbenzoic acid (3), were characterized from the EtOAc extracts of the Ascidian-derived endophytic fungus Aspergillus clavatus AS-107. The absolute configuration of compound 1 was established by electronic circular dichroism quantum calculation and the structure of compound 3 was elucidated on the basis of spectroscopic data together with single-crystal X-ray diffraction experiment. The isolated compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1 and 2 showed potent activity against aquatic pathogens Aeromonas hydrophilia and Pseudomonas aeruginosa with MIC values of 8.2 and 8.8 mu M, respectively.
KeywordAscidian-derived fungus Aspergillus clavatus Secondary metabolites Antibacterial activity
DOI10.1016/j.phytol.2019.09.004
Indexed BySCI
Language英语
Funding ProjectNSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000498702200006
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163808
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Song, Qi,Li, Xiao-Ming,Hu, Xue-Yi,et al. Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107[J]. PHYTOCHEMISTRY LETTERS,2019,34:30-34.
APA Song, Qi.,Li, Xiao-Ming.,Hu, Xue-Yi.,Li, Xin.,Chi, Lu-Ping.,...&Wang, Bin-Gui.(2019).Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107.PHYTOCHEMISTRY LETTERS,34,30-34.
MLA Song, Qi,et al."Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107".PHYTOCHEMISTRY LETTERS 34(2019):30-34.
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