Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107

doi:10.1016/j.phytol.2019.09.004

IOCAS-IR > 实验海洋生物学重点实验室

	Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107
	Song, Qi 1,2,3; Li, Xiao-Ming 1,2,4; Hu, Xue-Yi1,2 ; Li, Xin1,2,4 ; Chi, Lu-Ping 1,2,3; Li, Hong-Lei1,2,4 ; Wang, Bin-Gui1,2,4
	2019-12-01
Source Publication	PHYTOCHEMISTRY LETTERS
ISSN	1874-3900
Volume	34 Pages:30-34
Corresponding Author	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
Abstract	Six secondary metabolites including a new aminobenzoic peptide seco-clavatustide B (1) and a new clavatoic acid derivative 5-acetyl-2,4-dihydroxy-3-methylbenzoic acid (3), were characterized from the EtOAc extracts of the Ascidian-derived endophytic fungus Aspergillus clavatus AS-107. The absolute configuration of compound 1 was established by electronic circular dichroism quantum calculation and the structure of compound 3 was elucidated on the basis of spectroscopic data together with single-crystal X-ray diffraction experiment. The isolated compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1 and 2 showed potent activity against aquatic pathogens Aeromonas hydrophilia and Pseudomonas aeruginosa with MIC values of 8.2 and 8.8 mu M, respectively.
Keyword	Ascidian-derived fungus Aspergillus clavatus Secondary metabolites Antibacterial activity
DOI	10.1016/j.phytol.2019.09.004
Indexed By	SCI
Language	英语
Funding Project	NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China
WOS Research Area	Plant Sciences ; Pharmacology & Pharmacy
WOS Subject	Plant Sciences ; Chemistry, Medicinal
WOS ID	WOS:000498702200006
Publisher	ELSEVIER
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/163808
Collection	实验海洋生物学重点实验室
Corresponding Author	Wang, Bin-Gui
Affiliation	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Song, Qi,Li, Xiao-Ming,Hu, Xue-Yi,et al. Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107[J]. PHYTOCHEMISTRY LETTERS,2019,34:30-34.
APA	Song, Qi.,Li, Xiao-Ming.,Hu, Xue-Yi.,Li, Xin.,Chi, Lu-Ping.,...&Wang, Bin-Gui.(2019).Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107.PHYTOCHEMISTRY LETTERS,34,30-34.
MLA	Song, Qi,et al."Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107".PHYTOCHEMISTRY LETTERS 34(2019):30-34.

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