Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea

doi:10.1021/acs.orglett.9b02856

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	Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea
	Yan, Pengcheng 1; Li, Ge ; Wang, Chaojie ; Wu, Jianzhang 1; Sun, Zhongmin 2; Martin, Gary E.3; Wang, Xiao 4; Reibarkh, Mikhail 4; Sauri, Josep 5; Gustafson, Kirk R.1,6
	2019-09-20
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	21 Issue:18 Pages:7577-7581
Corresponding Author	Yan, Pengcheng(yanpc@wmu.edu.cn) ; Wu, Jianzhang(wujianzhang@wmu.edu.cn) ; Gustafson, Kirk R.(gustafki@mail.nih.gov)
Abstract	The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
DOI	10.1021/acs.orglett.9b02856
Indexed By	SCI
Language	英语
Funding Project	Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
WOS Research Area	Chemistry
WOS Subject	Chemistry, Organic
WOS ID	WOS:000487577200081
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/162987
Collection	中国科学院海洋研究所
Corresponding Author	Yan, Pengcheng; Wu, Jianzhang; Gustafson, Kirk R.
Affiliation	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 3.Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA 4.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Rahway, NJ 07065 USA 5.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Boston, MA 02115 USA 6.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA
Recommended Citation GB/T 7714	Yan, Pengcheng,Li, Ge,Wang, Chaojie,et al. Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea[J]. ORGANIC LETTERS,2019,21(18):7577-7581.
APA	Yan, Pengcheng.,Li, Ge.,Wang, Chaojie.,Wu, Jianzhang.,Sun, Zhongmin.,...&Gustafson, Kirk R..(2019).Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea.ORGANIC LETTERS,21(18),7577-7581.
MLA	Yan, Pengcheng,et al."Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea".ORGANIC LETTERS 21.18(2019):7577-7581.

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