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| Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea | |
| Yan, Pengcheng1; Li, Ge; Wang, Chaojie; Wu, Jianzhang1; Sun, Zhongmin2; Martin, Gary E.3; Wang, Xiao4; Reibarkh, Mikhail4; Sauri, Josep5; Gustafson, Kirk R.1,6 | |
| 2019-09-20 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 21Issue:18Pages:7577-7581 |
| Corresponding Author | Yan, Pengcheng(yanpc@wmu.edu.cn) ; Wu, Jianzhang(wujianzhang@wmu.edu.cn) ; Gustafson, Kirk R.(gustafki@mail.nih.gov) |
| Abstract | The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1. |
| DOI | 10.1021/acs.orglett.9b02856 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research ; Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000487577200081 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/162987 |
| Collection | 中国科学院海洋研究所 |
| Corresponding Author | Yan, Pengcheng; Wu, Jianzhang; Gustafson, Kirk R. |
| Affiliation | 1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 3.Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA 4.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Rahway, NJ 07065 USA 5.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Boston, MA 02115 USA 6.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA |
| Recommended Citation GB/T 7714 | Yan, Pengcheng,Li, Ge,Wang, Chaojie,et al. Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea[J]. ORGANIC LETTERS,2019,21(18):7577-7581. |
| APA | Yan, Pengcheng.,Li, Ge.,Wang, Chaojie.,Wu, Jianzhang.,Sun, Zhongmin.,...&Gustafson, Kirk R..(2019).Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea.ORGANIC LETTERS,21(18),7577-7581. |
| MLA | Yan, Pengcheng,et al."Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea".ORGANIC LETTERS 21.18(2019):7577-7581. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Yan-2019-Characteriz（989KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | ||
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