IOCAS-IR
Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea
Yan, Pengcheng1; Li, Ge; Wang, Chaojie; Wu, Jianzhang1; Sun, Zhongmin2; Martin, Gary E.3; Wang, Xiao4; Reibarkh, Mikhail4; Sauri, Josep5; Gustafson, Kirk R.1,6
2019-09-20
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:18Pages:7577-7581
Corresponding AuthorYan, Pengcheng(yanpc@wmu.edu.cn) ; Wu, Jianzhang(wujianzhang@wmu.edu.cn) ; Gustafson, Kirk R.(gustafki@mail.nih.gov)
AbstractThe challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
DOI10.1021/acs.orglett.9b02856
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000487577200081
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/162987
Collection中国科学院海洋研究所
Corresponding AuthorYan, Pengcheng; Wu, Jianzhang; Gustafson, Kirk R.
Affiliation1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
3.Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA
4.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Rahway, NJ 07065 USA
5.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Boston, MA 02115 USA
6.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA
Recommended Citation
GB/T 7714
Yan, Pengcheng,Li, Ge,Wang, Chaojie,et al. Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea[J]. ORGANIC LETTERS,2019,21(18):7577-7581.
APA Yan, Pengcheng.,Li, Ge.,Wang, Chaojie.,Wu, Jianzhang.,Sun, Zhongmin.,...&Gustafson, Kirk R..(2019).Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea.ORGANIC LETTERS,21(18),7577-7581.
MLA Yan, Pengcheng,et al."Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea".ORGANIC LETTERS 21.18(2019):7577-7581.
Files in This Item:
File Name/Size DocType Version Access License
Yan-2019-Characteriz(989KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yan, Pengcheng]'s Articles
[Li, Ge]'s Articles
[Wang, Chaojie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yan, Pengcheng]'s Articles
[Li, Ge]'s Articles
[Wang, Chaojie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yan, Pengcheng]'s Articles
[Li, Ge]'s Articles
[Wang, Chaojie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.