IOCAS-IR  > 实验海洋生物学重点实验室
Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
Yang, Haoyue1,2,3; Xing, Ronge1,2,3; Liu, Song1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
2019-01-24
Source PublicationPHARMACEUTICAL BIOLOGY
ISSN1388-0209
Volume57Issue:1Pages:29-37
Corresponding AuthorXing, Ronge(xingronge@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractContext: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, gamma-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Materials and methods: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. Results: GABA supplementation in fluoride-exposed mice significantly increased the expression of thyroid TG, TPO, and NIS (P < 0.05), significantly improved the thyroid redox state (P < 0.05), modulated the expression of thyroid function-associated genes, conferred liver metabolic protection, and prevented changes to myocardial morphology, thus reducing side effects. Both pure and laboratory-separated GABA displayed comparative protective effects. Discussion and conclusion: Our findings support the assertion that GABA exerts therapeutic potential in hypothyroidism. The design and use of human GABA trials to improve therapeutic outcomes in hypothyroidism are now warranted.
KeywordGABA thyroid hormone synthesis myocardial preservation anti-hypothyroidism
DOI10.1080/13880209.2018.1563621
Indexed BySCI
Language英语
Funding ProjectKey Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; Commonwealth of State Oceanic Administration People's Republic of China[201405038-2] ; Innovation and Development of Marine Economy Demonstration City Project ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02]
WOS Research AreaPlant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS IDWOS:000457344700001
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/160609
Collection实验海洋生物学重点实验室
Corresponding AuthorXing, Ronge; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice[J]. PHARMACEUTICAL BIOLOGY,2019,57(1):29-37.
APA Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2019).Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.PHARMACEUTICAL BIOLOGY,57(1),29-37.
MLA Yang, Haoyue,et al."Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice".PHARMACEUTICAL BIOLOGY 57.1(2019):29-37.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Haoyue]'s Articles
[Xing, Ronge]'s Articles
[Liu, Song]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Haoyue]'s Articles
[Xing, Ronge]'s Articles
[Liu, Song]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Haoyue]'s Articles
[Xing, Ronge]'s Articles
[Liu, Song]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.