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| Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice | |
Yang, Haoyue1,2,3 ; Xing, Ronge1,2,3; Liu, Song1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
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| 2019-01-24 | |
| 发表期刊 | PHARMACEUTICAL BIOLOGY
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| ISSN | 1388-0209 |
| 卷号 | 57期号:1页码:29-37 |
| 通讯作者 | Xing, Ronge(xingronge@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn) |
| 摘要 | Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, gamma-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Materials and methods: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. Results: GABA supplementation in fluoride-exposed mice significantly increased the expression of thyroid TG, TPO, and NIS (P < 0.05), significantly improved the thyroid redox state (P < 0.05), modulated the expression of thyroid function-associated genes, conferred liver metabolic protection, and prevented changes to myocardial morphology, thus reducing side effects. Both pure and laboratory-separated GABA displayed comparative protective effects. Discussion and conclusion: Our findings support the assertion that GABA exerts therapeutic potential in hypothyroidism. The design and use of human GABA trials to improve therapeutic outcomes in hypothyroidism are now warranted. |
| 关键词 | GABA thyroid hormone synthesis myocardial preservation anti-hypothyroidism |
| DOI | 10.1080/13880209.2018.1563621 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; Commonwealth of State Oceanic Administration People's Republic of China[201405038-2] ; Innovation and Development of Marine Economy Demonstration City Project ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; Commonwealth of State Oceanic Administration People's Republic of China[201405038-2] ; Innovation and Development of Marine Economy Demonstration City Project ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] |
| WOS研究方向 | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000457344700001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/160609 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge; Li, Pengcheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice[J]. PHARMACEUTICAL BIOLOGY,2019,57(1):29-37. |
| APA | Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2019).Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.PHARMACEUTICAL BIOLOGY,57(1),29-37. |
| MLA | Yang, Haoyue,et al."Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice".PHARMACEUTICAL BIOLOGY 57.1(2019):29-37. |
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