IOCAS-IR  > 实验海洋生物学重点实验室
Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa
Sun, Yuhao1,2,3,4; Chen, Xiaolin1,2,4; Song, Lin5; Liu, Song1,2,4; Yu, Huahua1,2,4; Wang, Xueqin1,2,4; Qin, Yukun1,2,4; Li, Pengcheng1,2,4
2018
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Pages11
Corresponding AuthorChen, Xiaolin(chenxl@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractAvian Leukosis Virus Subgroup J (ALV-J), a retrovirus of avian, has caused enormous economics losses to poultry industry around the world. Polysaccharides from marine algae are featured diversity bioactivities. To find the potential effect to prevent ALV-J spread, in this study, polysaccharides from Ulva pertusa (UPPs) and four low molecular weight (Mw) U. pertusa polysaccharides (LUPPs) were prepared and their functions on ALV-J were investigated. Firstly, LUP Ps were obtained by hydrogen peroxide (H2O2) oxidative degradation. The effects of degradation conditions on Mw of the UPP were also investigated. Results showed that the H2O2 oxidative degradation method could degrade UPP effectively, and the degradation was positively related to H2O, concentration and temperature and negatively to pH. The chemical characteristics of UPP and LUPPs were also determined. Afterwards, the anti-ALVJ activity of the polysaccharides were carried out in vitro. Results showed that UPP and LUPPs could inhibit ALV-J and LUPP-3 and Mw of 4.3 ki)a exerted the strongest suppression. The action phase assay showed that LUPP-3 could bind with the viral particles and prevented ALV-J adsorption onto the host cells. And the ALV-J relative gene and gp85 protein expression were significantly suppressed after being administration with LUPP-3. Therefore, the low Mw polysaccharides from U. pertusa have great potential as an anti-ALV-J drug alternative.
DOI10.1155/2018/9415965
Indexed BySCI
Language英语
Funding ProjectShandong Province Key Research and Development Project[2016YYSP010] ; NSFC-Shandong Joint Fund[U1606403] ; Qingdao People's Livelihood Science and Technology Projects[16-6-2-41-nsh]
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000442101000001
PublisherHINDAWI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/159871
Collection实验海洋生物学重点实验室
Corresponding AuthorChen, Xiaolin; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
5.Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Qingdao 266042, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Yuhao,Chen, Xiaolin,Song, Lin,et al. Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa[J]. BIOMED RESEARCH INTERNATIONAL,2018:11.
APA Sun, Yuhao.,Chen, Xiaolin.,Song, Lin.,Liu, Song.,Yu, Huahua.,...&Li, Pengcheng.(2018).Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa.BIOMED RESEARCH INTERNATIONAL,11.
MLA Sun, Yuhao,et al."Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa".BIOMED RESEARCH INTERNATIONAL (2018):11.
Files in This Item:
File Name/Size DocType Version Access License
Antiviral Activity a(2880KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Yuhao]'s Articles
[Chen, Xiaolin]'s Articles
[Song, Lin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Yuhao]'s Articles
[Chen, Xiaolin]'s Articles
[Song, Lin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Yuhao]'s Articles
[Chen, Xiaolin]'s Articles
[Song, Lin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.