Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa

doi:10.1155/2018/9415965

IOCAS-IR > 实验海洋生物学重点实验室

	Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa
	Sun, Yuhao1,2,3,4 ; Chen, Xiaolin 1,2,4; Song, Lin5 ; Liu, Song 1,2,4; Yu, Huahua1,2,4 ; Wang, Xueqin 1,2,4; Qin, Yukun 1,2,4; Li, Pengcheng1,2,4
	2018
发表期刊	BIOMED RESEARCH INTERNATIONAL
ISSN	2314-6133
页码	11
通讯作者	Chen, Xiaolin(chenxl@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
摘要	Avian Leukosis Virus Subgroup J (ALV-J), a retrovirus of avian, has caused enormous economics losses to poultry industry around the world. Polysaccharides from marine algae are featured diversity bioactivities. To find the potential effect to prevent ALV-J spread, in this study, polysaccharides from Ulva pertusa (UPPs) and four low molecular weight (Mw) U. pertusa polysaccharides (LUPPs) were prepared and their functions on ALV-J were investigated. Firstly, LUP Ps were obtained by hydrogen peroxide (H2O2) oxidative degradation. The effects of degradation conditions on Mw of the UPP were also investigated. Results showed that the H2O2 oxidative degradation method could degrade UPP effectively, and the degradation was positively related to H2O, concentration and temperature and negatively to pH. The chemical characteristics of UPP and LUPPs were also determined. Afterwards, the anti-ALVJ activity of the polysaccharides were carried out in vitro. Results showed that UPP and LUPPs could inhibit ALV-J and LUPP-3 and Mw of 4.3 ki)a exerted the strongest suppression. The action phase assay showed that LUPP-3 could bind with the viral particles and prevented ALV-J adsorption onto the host cells. And the ALV-J relative gene and gp85 protein expression were significantly suppressed after being administration with LUPP-3. Therefore, the low Mw polysaccharides from U. pertusa have great potential as an anti-ALV-J drug alternative.
DOI	10.1155/2018/9415965
收录类别	SCI
语种	英语
资助项目	Shandong Province Key Research and Development Project[2016YYSP010] ; NSFC-Shandong joint Fund[U1606403] ; Qingdao People's Livelihood Science and Technology Projects[16-6-2-41-nsh] ; Shandong Province Key Research and Development Project[2016YYSP010] ; NSFC-Shandong Joint Fund[U1606403] ; Qingdao People's Livelihood Science and Technology Projects[16-6-2-41-nsh]
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS记录号	WOS:000442101000001
出版者	HINDAWI LTD
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/159871
专题	实验海洋生物学重点实验室
通讯作者	Chen, Xiaolin; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 5.Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Qingdao 266042, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Sun, Yuhao,Chen, Xiaolin,Song, Lin,et al. Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa[J]. BIOMED RESEARCH INTERNATIONAL,2018:11.
APA	Sun, Yuhao.,Chen, Xiaolin.,Song, Lin.,Liu, Song.,Yu, Huahua.,...&Li, Pengcheng.(2018).Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa.BIOMED RESEARCH INTERNATIONAL,11.
MLA	Sun, Yuhao,et al."Antiviral Activity against Avian Leucosis Virus Subgroup J of Degraded Polysaccharides from Ulva pertusa".BIOMED RESEARCH INTERNATIONAL (2018):11.

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