IOCAS-IR  > 海洋生物分类与系统演化实验室
First comprehensive analysis of lysine acetylation in Alvinocaris longirostris from the deep-sea hydrothermal vents
Hui, Min1,2; Cheng, Jiao1,2; Sha, Zhongli1,2,3
2018-05-10
Source PublicationBMC GENOMICS
ISSN1471-2164
Volume19Pages:13
Corresponding AuthorSha, Zhongli(shazl@qdio.ac.cn)
AbstractBackground: Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to play critical roles in the regulation of many cellular processes. However, its function in A. longirostris and even marine invertebrates remains elusive. Our study is the first, to our knowledge, to comprehensively investigate lysine acetylome in A. longirostris. Results: In total, 501 unique acetylation sites from 206 proteins were identified by combination of affinity enrichment and high-sensitive-massspectrometer. It was revealed that Arg, His and Lys occurred most frequently at the + 1 position downstream of the acetylation sites, which were all alkaline amino acids and positively charged. Functional analysis revealed that the protein acetylation was involved in diverse cellular processes, such as biosynthesis of amino acids, citrate cycle, fatty acid degradation and oxidative phosphorylation. Acetylated proteins were found enriched in mitochondrion and peroxisome, and many stress response related proteins were also discovered to be acetylated, like arginine kinases, heat shock protein 70, and hemocyanins. In the two hemocyanins, nine acetylation sites were identified, among which one acetylation site was unique in A. longirostris when compared with other shallow water shrimps. Further studies are warranted to verify its function. Conclusion: The lysine acetylome of A. longirostris is investigated for the first time and brings new insights into the regulation function of the lysine acetylation. The results supply abundant resources for exploring the functions of acetylation in A. longirostris and other shrimps.
KeywordAlvinocarididae Hemocyanins Hydrothermal vent Lysine acetylation Post-translational modification
DOI10.1186/s12864-018-4745-3
Indexed BySCI
Language英语
Funding ProjectKey Research Program of Frontier Sciences, Chinese Academy of Sciences[QYZDB-SSW-DQC036] ; Chinese Academy of Sciences[XDA1103040102]
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000431831000004
PublisherBIOMED CENTRAL LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158984
Collection海洋生物分类与系统演化实验室
深海极端环境与生命过程研究中心
Corresponding AuthorSha, Zhongli
Affiliation1.Chinese Acad Sci, Inst Oceanol, Lab Marine Organism Taxon & Phylogeny, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Deep Sea Res, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hui, Min,Cheng, Jiao,Sha, Zhongli. First comprehensive analysis of lysine acetylation in Alvinocaris longirostris from the deep-sea hydrothermal vents[J]. BMC GENOMICS,2018,19:13.
APA Hui, Min,Cheng, Jiao,&Sha, Zhongli.(2018).First comprehensive analysis of lysine acetylation in Alvinocaris longirostris from the deep-sea hydrothermal vents.BMC GENOMICS,19,13.
MLA Hui, Min,et al."First comprehensive analysis of lysine acetylation in Alvinocaris longirostris from the deep-sea hydrothermal vents".BMC GENOMICS 19(2018):13.
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