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Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547
Yang, Sui-Qun1,2,3; Li, Xiao-Ming1,2; Li, Xin1,2; Chi, Lu-Ping1,2,3; Wang, Bin-Gui1,2
2018-04-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:4Pages:9
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractChemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12 beta,15 alpha,25-trihydroxyergosta-4,6,8(14), 22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (4-7). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 1-7 were evaluated.
Keywordalgal-derived endophytic fungus Aspergillus alabamensis diketomorpholine steroid antimicrobial activity
DOI10.3390/md16040114
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000431068000016
PublisherMDPI
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158942
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,et al. Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547[J]. MARINE DRUGS,2018,16(4):9.
APA Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,Chi, Lu-Ping,&Wang, Bin-Gui.(2018).Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547.MARINE DRUGS,16(4),9.
MLA Yang, Sui-Qun,et al."Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547".MARINE DRUGS 16.4(2018):9.
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