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| Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547 | |
Yang, Sui-Qun1,2,3; Li, Xiao-Ming1,2; Li, Xin1,2 ; Chi, Lu-Ping1,2,3; Wang, Bin-Gui1,2
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| 2018-04-01 | |
| 发表期刊 | MARINE DRUGS
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| ISSN | 1660-3397 |
| 卷号 | 16期号:4页码:9 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 摘要 | Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12 beta,15 alpha,25-trihydroxyergosta-4,6,8(14), 22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (4-7). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 1-7 were evaluated. |
| 关键词 | algal-derived endophytic fungus Aspergillus alabamensis diketomorpholine steroid antimicrobial activity |
| DOI | 10.3390/md16040114 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China ; Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:000431068000016 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/158942 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,et al. Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547[J]. MARINE DRUGS,2018,16(4):9. |
| APA | Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,Chi, Lu-Ping,&Wang, Bin-Gui.(2018).Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547.MARINE DRUGS,16(4),9. |
| MLA | Yang, Sui-Qun,et al."Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547".MARINE DRUGS 16.4(2018):9. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Two New Diketomorpho（3753KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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