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Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection
Li, Mo-Fei1,2; Sun, Li1,2
2018-02-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume79Pages:142-149
Corresponding AuthorSun, Li(lsun@qdio.ac.cn)
AbstractIn mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region. CsMCRP expression occurred in nine different tissues, especially blood, and in peripheral blood leukocytes (PBL). Recombinant CsMCRP inhibited complement activation and interacted with bacterial pathogen, the latter in a highly selective manner. Antibody blocking the CsMCRP on PBL significantly inhibited bacterial infection of PBL. These results indicate that teleost CsMCRP is both a regulator of complement activation and a cellular receptor involved in bacterial invasion. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordComplement regulatory protein Complement activation Cynoglossus semilaevis Bacterial infection
DOI10.1016/j.dci.2017.10.008
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31330081] ; AoShan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS IDWOS:000422811500016
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157817
Collection实验海洋生物学重点实验室
Corresponding AuthorSun, Li
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Mo-Fei,Sun, Li. Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,79:142-149.
APA Li, Mo-Fei,&Sun, Li.(2018).Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,79,142-149.
MLA Li, Mo-Fei,et al."Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 79(2018):142-149.
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