Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection | |
Li, Mo-Fei1,2 ; Sun, Li1,2
| |
| 2018-02-01 | |
| 发表期刊 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| ISSN | 0145-305X |
| 卷号 | 79页码:142-149 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
| 摘要 | In mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region. CsMCRP expression occurred in nine different tissues, especially blood, and in peripheral blood leukocytes (PBL). Recombinant CsMCRP inhibited complement activation and interacted with bacterial pathogen, the latter in a highly selective manner. Antibody blocking the CsMCRP on PBL significantly inhibited bacterial infection of PBL. These results indicate that teleost CsMCRP is both a regulator of complement activation and a cellular receptor involved in bacterial invasion. (C) 2017 Elsevier Ltd. All rights reserved. |
| 关键词 | Complement regulatory protein Complement activation Cynoglossus semilaevis Bacterial infection |
| DOI | 10.1016/j.dci.2017.10.008 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31330081] ; Aoshan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province ; National Natural Science Foundation of China[31330081] ; AoShan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Fisheries ; Immunology ; Zoology |
| WOS类目 | Fisheries ; Immunology ; Zoology |
| WOS记录号 | WOS:000422811500016 |
| 出版者 | ELSEVIER SCI LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/157817 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Mo-Fei,Sun, Li. Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,79:142-149. |
| APA | Li, Mo-Fei,&Sun, Li.(2018).Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,79,142-149. |
| MLA | Li, Mo-Fei,et al."Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 79(2018):142-149. |
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