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Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291
Zhang, Peng1,2; Li, Xiao-Ming1; Mao, Xin-Xin2; Mandi, Attila3; Kurtan, Tibor3; Wang, Bin-Gui1
2016-09-09
Source PublicationBEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
ISSN1860-5397
Volume12Pages:2012-2018
Corresponding AuthorKurtan, Tibor(kurtan.tibor@science.unideb.hu) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractA new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative, varioloid A (1), was isolated from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291. Its structure was elucidated on the basis of extensive analysis of 1D and 2D NMR data and the absolute configuration was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. A similar compound, whose planar structure was previously described but the relative and absolute configurations and C-13 NMR data were not reported, was also identified and was tentatively named as varioloid B (2). Both compounds 1 and 2 exhibited cytotoxicity against A549, HCT116, and HepG2 cell lines, with IC50 values ranging from 2.6 to 8.2 mu g/mL.
Keywordbisindolyl benzenoid derivatives cytotoxicity marine alga-derived fungus Paecilomyces variotii TDDFT-ECD calculation
DOI10.3762/bjoc.12.188
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Hungarian National Research Foundation (OTKA)[K105871]
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000382737600001
PublisherBEILSTEIN-INSTITUT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157258
Collection实验海洋生物学重点实验室
Corresponding AuthorKurtan, Tibor; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Peng,Li, Xiao-Ming,Mao, Xin-Xin,et al. Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2016,12:2012-2018.
APA Zhang, Peng,Li, Xiao-Ming,Mao, Xin-Xin,Mandi, Attila,Kurtan, Tibor,&Wang, Bin-Gui.(2016).Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,12,2012-2018.
MLA Zhang, Peng,et al."Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 12(2016):2012-2018.
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