| First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes | |
| Li, Yi-qun1,2,3; Zhang, Jian1,2; Li, Jun4; Sun, Li1,2 | |
| 2017-08-01 | |
| 发表期刊 | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
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| 卷号 | 190页码:39-44 |
| 文章类型 | Article |
| 摘要 | In mammals, CD22 is a member of the ig superfamily that serves as an inhibitor during B cell responses to foreign antigens. In this study, we characterized for the first time a fish CD22 from tongue sole Cynoglossus semilaevis (CsCD22). CsCD22 possesses the conserved structural features of CD22 and shares 35%-54% sequence identities with other fish CD22. mRNA expression of CsCD22 was most abundant in head kidney and heart. CSCD22 protein was detected on the surface of peripheral blood leukocytes (PBL). In the presence of rCsCD22 antibody, the proliferation, phagocytosis, and antibacterial activity of PBL were significantly increased. These results indicate for the first time that fish CD22 plays an inhibitory role in PBL activation. |
| 关键词 | Cd22 Cynoglossus Semilaevis Peripheral Blood Leukocytes Phagocytosis Immune Inhibition |
| DOI | 10.1016/j.vetimm.2016.07.006 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000408182900006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/143153 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA |
| 推荐引用方式 GB/T 7714 | Li, Yi-qun,Zhang, Jian,Li, Jun,et al. First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2017,190:39-44. |
| APA | Li, Yi-qun,Zhang, Jian,Li, Jun,&Sun, Li.(2017).First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,190,39-44. |
| MLA | Li, Yi-qun,et al."First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 190(2017):39-44. |
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| First characterizati（2624KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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