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First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes
Li, Yi-qun1,2,3; Zhang, Jian1,2; Li, Jun4; Sun, Li1,2
2017-08-01
发表期刊VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷号190页码:39-44
文章类型Article
摘要In mammals, CD22 is a member of the ig superfamily that serves as an inhibitor during B cell responses to foreign antigens. In this study, we characterized for the first time a fish CD22 from tongue sole Cynoglossus semilaevis (CsCD22). CsCD22 possesses the conserved structural features of CD22 and shares 35%-54% sequence identities with other fish CD22. mRNA expression of CsCD22 was most abundant in head kidney and heart. CSCD22 protein was detected on the surface of peripheral blood leukocytes (PBL). In the presence of rCsCD22 antibody, the proliferation, phagocytosis, and antibacterial activity of PBL were significantly increased. These results indicate for the first time that fish CD22 plays an inhibitory role in PBL activation.
关键词Cd22 Cynoglossus Semilaevis Peripheral Blood Leukocytes Phagocytosis Immune Inhibition
DOI10.1016/j.vetimm.2016.07.006
收录类别SCI
语种英语
WOS记录号WOS:000408182900006
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文献类型期刊论文
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条目标识符http://ir.qdio.ac.cn/handle/337002/143153
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA
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Li, Yi-qun,Zhang, Jian,Li, Jun,et al. First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2017,190:39-44.
APA Li, Yi-qun,Zhang, Jian,Li, Jun,&Sun, Li.(2017).First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,190,39-44.
MLA Li, Yi-qun,et al."First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 190(2017):39-44.
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