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First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes
Li, Yi-qun1,2,3; Zhang, Jian1,2; Li, Jun4; Sun, Li1,2
2017-08-01
Source PublicationVETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume190Pages:39-44
SubtypeArticle
AbstractIn mammals, CD22 is a member of the ig superfamily that serves as an inhibitor during B cell responses to foreign antigens. In this study, we characterized for the first time a fish CD22 from tongue sole Cynoglossus semilaevis (CsCD22). CsCD22 possesses the conserved structural features of CD22 and shares 35%-54% sequence identities with other fish CD22. mRNA expression of CsCD22 was most abundant in head kidney and heart. CSCD22 protein was detected on the surface of peripheral blood leukocytes (PBL). In the presence of rCsCD22 antibody, the proliferation, phagocytosis, and antibacterial activity of PBL were significantly increased. These results indicate for the first time that fish CD22 plays an inhibitory role in PBL activation.
KeywordCd22 Cynoglossus Semilaevis Peripheral Blood Leukocytes Phagocytosis Immune Inhibition
DOI10.1016/j.vetimm.2016.07.006
Indexed BySCI
Language英语
WOS IDWOS:000408182900006
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143153
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA
First Author Affilication中国科学院海洋研究所
Recommended Citation
GB/T 7714
Li, Yi-qun,Zhang, Jian,Li, Jun,et al. First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2017,190:39-44.
APA Li, Yi-qun,Zhang, Jian,Li, Jun,&Sun, Li.(2017).First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,190,39-44.
MLA Li, Yi-qun,et al."First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 190(2017):39-44.
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