| First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes | |
| Li, Yi-qun1,2,3; Zhang, Jian1,2; Li, Jun4; Sun, Li1,2 | |
| 2017-08-01 | |
| Source Publication | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
 |
| Volume | 190Pages:39-44 |
| Subtype | Article |
| Abstract | In mammals, CD22 is a member of the ig superfamily that serves as an inhibitor during B cell responses to foreign antigens. In this study, we characterized for the first time a fish CD22 from tongue sole Cynoglossus semilaevis (CsCD22). CsCD22 possesses the conserved structural features of CD22 and shares 35%-54% sequence identities with other fish CD22. mRNA expression of CsCD22 was most abundant in head kidney and heart. CSCD22 protein was detected on the surface of peripheral blood leukocytes (PBL). In the presence of rCsCD22 antibody, the proliferation, phagocytosis, and antibacterial activity of PBL were significantly increased. These results indicate for the first time that fish CD22 plays an inhibitory role in PBL activation. |
| Keyword | Cd22 Cynoglossus Semilaevis Peripheral Blood Leukocytes Phagocytosis Immune Inhibition |
| DOI | 10.1016/j.vetimm.2016.07.006 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000408182900006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/143153 |
| Collection | 实验海洋生物学重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA |
| First Author Affilication | 中国科学院海洋研究所 |
| Recommended Citation GB/T 7714 | Li, Yi-qun,Zhang, Jian,Li, Jun,et al. First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2017,190:39-44. |
| APA | Li, Yi-qun,Zhang, Jian,Li, Jun,&Sun, Li.(2017).First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,190,39-44. |
| MLA | Li, Yi-qun,et al."First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 190(2017):39-44. |
| Files in This Item: | ||||||
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| First characterizati（2624KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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