| Rescuing fluoride-induced damages in liver with gamma aminobutyric acid | |
Yang, Haoyue1,2 ; Xing, Ronge1,2; Liu, Song1,2; Yu, Huahua1,2; Li, Pengcheng1,2
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| 2017-09-09 | |
| 发表期刊 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 卷号 | 491期号:1页码:19-24 |
| 文章类型 | Article |
| 摘要 | Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-minobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice. This detoxification was reflected by the reduced oxidative stress and apoptosis, enhanced neuron protection and liver function. Collectively, this study provided evidence of the beneficial effects of GABA supplement on liver damage, implicating its therapeutic potential in fluorosis. (C) 2017 Elsevier Inc. All rights reserved. |
| 关键词 | Fluorosis Liver Gaba Oxidative Stress |
| DOI | 10.1016/j.bbrc.2017.07.015 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000408518700004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/143136 |
| 专题 | 海洋生物技术研发中心 海洋环境工程技术研究发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所; 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Rescuing fluoride-induced damages in liver with gamma aminobutyric acid[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,491(1):19-24. |
| APA | Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2017).Rescuing fluoride-induced damages in liver with gamma aminobutyric acid.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,491(1),19-24. |
| MLA | Yang, Haoyue,et al."Rescuing fluoride-induced damages in liver with gamma aminobutyric acid".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 491.1(2017):19-24. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Rescuing fluoride-in（1498KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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