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Rescuing fluoride-induced damages in liver with gamma aminobutyric acid
Yang, Haoyue1,2; Xing, Ronge1,2; Liu, Song1,2; Yu, Huahua1,2; Li, Pengcheng1,2
2017-09-09
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume491Issue:1Pages:19-24
SubtypeArticle
AbstractFluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-minobutyric acid (GABA), a liver protector reported previously, on fluoride-induced damage in the mouse liver. Through microscope imaging of the liver tissue, TUNEL immunostaining, real-time RT-PCR, enzyme immunoassay and colorimetric method, we found that GABA supplementation prevented the metabolic toxicity caused by fluoride treatment in mice. This detoxification was reflected by the reduced oxidative stress and apoptosis, enhanced neuron protection and liver function. Collectively, this study provided evidence of the beneficial effects of GABA supplement on liver damage, implicating its therapeutic potential in fluorosis. (C) 2017 Elsevier Inc. All rights reserved.
KeywordFluorosis Liver Gaba Oxidative Stress
DOI10.1016/j.bbrc.2017.07.015
Indexed BySCI
Language英语
WOS IDWOS:000408518700004
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143136
Collection海洋生物技术研发中心
海洋环境工程技术研究发展中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Rescuing fluoride-induced damages in liver with gamma aminobutyric acid[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,491(1):19-24.
APA Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2017).Rescuing fluoride-induced damages in liver with gamma aminobutyric acid.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,491(1),19-24.
MLA Yang, Haoyue,et al."Rescuing fluoride-induced damages in liver with gamma aminobutyric acid".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 491.1(2017):19-24.
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