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The first CUB-domain containing serine protease from Chlamys farreri which might be involved in larval development and immune response
Yang, Chuanyan1; Wang, Leilei3; Zhang, Huan3; Yi, Qilin1; Wang, Lingling1,2; Wang, Hao3; Song, Linsheng1,2
2017-11-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号76页码:163-168
文章类型Article
摘要Serine proteases (SPs) are one of the most well understood enzyme families, which play an important role in regulating many physiological events. In the present study, one CUB-domain containing serine protease was identified from Chlamys farreri (designated as CfCUBSP). The full-length cDNA of CfCUBSP was of 3181 bp with an open reading frame of 2688 bp encoding a polypeptide of 896 amino acids. CfCUBSP shared closer phylogenetic relationship with those multi-domain SPs which consisted of one SP domain, and different numbers of CUB domain and LDLa domain than other SPs. The mRNA transcripts of CfCUBSP were detected in all developmental stages with the highest expression level in fertilized eggs and the lowest in trochophore larvae. In adult scallop, the CfCUBSP mRNA could be detected in all examined tissues with the highest level in hepatopancreas, and CfCUBSP protein was dominantly located in the gills, hepatopancreas, gonad and kidney. The mRNA expression of CfCUBSP in hemocytes was significantly up-regulated after the stimulation of lipopolysaccharide (LPS), peptidoglycan (PGN) and beta-glucan (GLU) (P < 0.05). All the results collectively indicated that CfCUBSP was a primitive member of the invertebrate SPs which might be involved in larval development and immune response against Gramnegative (G-) and Gram-positive (G+) bacteria and fungus in scallop. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Chlamys Farreri Cubsp Immune Response Larval Development
DOI10.1016/j.dci.2017.05.024
收录类别SCI
语种英语
WOS记录号WOS:000407985100017
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143111
专题实验海洋生物学重点实验室
作者单位1.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian 116023, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
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Yang, Chuanyan,Wang, Leilei,Zhang, Huan,et al. The first CUB-domain containing serine protease from Chlamys farreri which might be involved in larval development and immune response[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,76:163-168.
APA Yang, Chuanyan.,Wang, Leilei.,Zhang, Huan.,Yi, Qilin.,Wang, Lingling.,...&Song, Linsheng.(2017).The first CUB-domain containing serine protease from Chlamys farreri which might be involved in larval development and immune response.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,76,163-168.
MLA Yang, Chuanyan,et al."The first CUB-domain containing serine protease from Chlamys farreri which might be involved in larval development and immune response".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 76(2017):163-168.
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