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Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus
Kong, Fan-Dong1; Zhang, Ren-Shuai3; Ma, Qing-Yun1; Xie, Qing-Yi1; Wang, Pei1; Chen, Peng-Wei1; Zhou, Li-Man1; Dai, Hao-Fu1; Luo, Du-Qiang2; Zhao, You-Xing1
2017-10-01
Source PublicationFITOTERAPIA
Volume122Pages:1-6
SubtypeArticle
AbstractFive new meroterpenoids, chrodrimanins O-S (1-5), as well as a known one (6), were isolated from the fermentation broth of Penicillium sp. SCS-ICED09 isolated from a marine worm, Sipunculusnudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Among them, compound 1 represents the first example of an unusual trichlorinated meroterpenoid with an unique dichlorine functionality. Compounds 1 and 4-6 displayed inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 71.6, 62.5, 63.1, and 39.6 mu M, respectively, and showed no apparent activity against three tumor cell lines (A549, HepG2, and Hela) and human umbilical vein endothelial cells (HUVEC) at 10 mu M.
KeywordPenicillitun Sp. Chrodrimanins Fungus Protein Tyrosine Phosphatase 1b Inhibition
DOI10.1016/j.fitote.2017.08.002
Indexed BySCI
Language英语
WOS IDWOS:000413383500001
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143046
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
2.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Kong, Fan-Dong,Zhang, Ren-Shuai,Ma, Qing-Yun,et al. Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus[J]. FITOTERAPIA,2017,122:1-6.
APA Kong, Fan-Dong.,Zhang, Ren-Shuai.,Ma, Qing-Yun.,Xie, Qing-Yi.,Wang, Pei.,...&Zhao, You-Xing.(2017).Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus.FITOTERAPIA,122,1-6.
MLA Kong, Fan-Dong,et al."Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus".FITOTERAPIA 122(2017):1-6.
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