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Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus
Kong, Fan-Dong1; Zhang, Ren-Shuai3; Ma, Qing-Yun1; Xie, Qing-Yi1; Wang, Pei1; Chen, Peng-Wei1; Zhou, Li-Man1; Dai, Hao-Fu1; Luo, Du-Qiang2; Zhao, You-Xing1
2017-10-01
发表期刊FITOTERAPIA
卷号122页码:1-6
文章类型Article
摘要Five new meroterpenoids, chrodrimanins O-S (1-5), as well as a known one (6), were isolated from the fermentation broth of Penicillium sp. SCS-ICED09 isolated from a marine worm, Sipunculusnudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Among them, compound 1 represents the first example of an unusual trichlorinated meroterpenoid with an unique dichlorine functionality. Compounds 1 and 4-6 displayed inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 71.6, 62.5, 63.1, and 39.6 mu M, respectively, and showed no apparent activity against three tumor cell lines (A549, HepG2, and Hela) and human umbilical vein endothelial cells (HUVEC) at 10 mu M.
关键词Penicillitun Sp. Chrodrimanins Fungus Protein Tyrosine Phosphatase 1b Inhibition
DOI10.1016/j.fitote.2017.08.002
收录类别SCI
语种英语
WOS记录号WOS:000413383500001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143046
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
2.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
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Kong, Fan-Dong,Zhang, Ren-Shuai,Ma, Qing-Yun,et al. Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus[J]. FITOTERAPIA,2017,122:1-6.
APA Kong, Fan-Dong.,Zhang, Ren-Shuai.,Ma, Qing-Yun.,Xie, Qing-Yi.,Wang, Pei.,...&Zhao, You-Xing.(2017).Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus.FITOTERAPIA,122,1-6.
MLA Kong, Fan-Dong,et al."Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus".FITOTERAPIA 122(2017):1-6.
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