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Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva
Li Rongfeng1; Yu Huahua1; Yue Yang1,2; Liu Song1; Xing Rong'e1; Chen Xiaolin1; Li Pengcheng1
2017-07-01
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
Volume35Issue:4Pages:763-769
SubtypeArticle
AbstractSea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China. Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides. To investigate the bioactivities of the polysaccharides from sea cucumber H. fuscogliva, we prepared the sulfated polysaccharides (HfP) from sea cucumber H. fuscogliva using a protease hydrolysis method. Antioxidant activities of HfP were investigated, including hydroxyl radical scavenging activity and superoxide radical scavenging activity. And, the anticoagulant activities of HfP were studied, including the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT). The average molecular weight was 1 867.1 Da, with a sulfate content of 20.7%. In addition, the molar ratio of monosaccharide composition of HfP was Man: Rha: Glc A: Glc: Gal: Xyl: Fuc=0.083 6: 0.437: 0.134: 0:1.182: 0.748: 1. It had a strong antioxidant activity, the hydroxyl and superoxide radical scavenging activity EC50 of HfP was 3.74 and 0.037 mg/mL, respectively. It also showed a good anticoagulant activity in our study. The APTT of HfP was much higher than that of heparin sodium, and the PT and TT of HfP was close to that of heparin sodium at a low concentration. Therefore, HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry.
KeywordSulfated Polysaccharides Sea Cucumber Holothuria Fuscogliva Antioxidant Activity Anticoagulant Activity
DOI10.1007/s00343-017-5339-7
Indexed BySCI
Language英语
WOS IDWOS:000403701200006
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/137126
Collection海洋环境工程技术研究发展中心
实验海洋生物学重点实验室
海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li Rongfeng,Yu Huahua,Yue Yang,et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2017,35(4):763-769.
APA Li Rongfeng.,Yu Huahua.,Yue Yang.,Liu Song.,Xing Rong'e.,...&Li Pengcheng.(2017).Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,35(4),763-769.
MLA Li Rongfeng,et al."Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 35.4(2017):763-769.
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