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A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish
Li, Xue-peng1,2,3; Sun, Li1,2
2017-06-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号71页码:49-58
文章类型Article
摘要Complement factor B (Bf) is a component of the complement system. Following activation of the alternative pathway of the complement system, factor B is cleaved into Ba and Bb fragments. In fish, the Bf of rainbow trout is known to act as a C3 convertase, but the function of the Ba fragment is essentially unknown. In this study, we examined the expression patterns of tongue sole Cynoglossus semilaevis Bf (named CsBf) and the biological activity of the Ba fragment of CsBf (named CsBa). CsBf possesses the conserved domains of Bf and shares 39.9%-56.4% sequence identities With other fish Bf. CsBf expression was high in liver, muscle, and heart, and low in intestine, blood, and kidney. Bacterial infection significantly induced CsBf expression in kidney, spleen, and liver in a time-dependent manner. Recombinant CsBa (rCsBa) exhibited apparent binding capacities to bacteria and tongue sole peripheral blood leukocytes, and binding of rCsBa to bacteria inhibited bacterial growth. When overexpressed in tongue sole, CsBa significantly reduced bacterial dissemination in fish tissues. Together these results indicate for the first time that a fish Ba possesses antibacterial effect as well as immune cell-binding capacity, and thus probably plays a role in host immune defense against bacterial infection. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Complement Factor b Cynoglossus Semilaevis Antimicrobial Bacterial Infection
DOI10.1016/j.dci.2017.01.021
收录类别SCI
语种英语
WOS记录号WOS:000397834800006
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136727
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Li, Xue-peng,Sun, Li. A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,71:49-58.
APA Li, Xue-peng,&Sun, Li.(2017).A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,71,49-58.
MLA Li, Xue-peng,et al."A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 71(2017):49-58.
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