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Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus
Huang, Baoyu1,2,3; Meng, Jie1,2,3; Yang, Mei4,5; Xu, Fei1,3,4; Li, Xinzheng4,5; Li, Li1,2,3; Zhang, Guofan1,3,4
2017-06-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号71页码:82-87
文章类型Article
摘要Interferon regulatory factors (IRFs) are transcription factors that play important roles in immune defense, stress response, hematopoietic differentiation, and cell apoptosis. IRFs of invertebrate organisms and their functions remain largely unexplored. In the present study, for the first time new IRFs (BpIRF2 and MmIRF2) were identified in the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus. The open reading frame of BpIRF2 and MmIRF2 encoded putative proteins of 354 and 348 amino acids, respectively. Comparison and phylogenetic analysis revealed that both IRF2 proteins were new identified invertebrate IRF molecular. As transcriptional factors, both BpIRF2 and MmIRF2 could activate the interferon-stimulated response element-containing promoter and BpIRF2 could interact with itself. Moreover, both BpIRF2 and MmIRF2 were localized to the cytoplasm and nucleus. Collectively, these results demonstrated that IRF2 proteins might be crucial in the innate immunity of deep-sea and shallow-water mussels. (C) 2017 Published by Elsevier Ltd.
关键词Irf2 Deep-sea Mussel Isre Innate Immunity
DOI10.1016/j.dci.2017.01.015
收录类别SCI
语种英语
WOS记录号WOS:000397834800009
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136726
专题海洋生物技术研发中心
实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
5.Chinese Acad Sci, Dept Marine Organism Taxon & Phylogeny, Qingdao, Peoples R China
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Huang, Baoyu,Meng, Jie,Yang, Mei,et al. Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,71:82-87.
APA Huang, Baoyu.,Meng, Jie.,Yang, Mei.,Xu, Fei.,Li, Xinzheng.,...&Zhang, Guofan.(2017).Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,71,82-87.
MLA Huang, Baoyu,et al."Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 71(2017):82-87.
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