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Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus
Huang, Baoyu1,2,3; Meng, Jie1,2,3; Yang, Mei4,5; Xu, Fei1,3,4; Li, Xinzheng4,5; Li, Li1,2,3; Zhang, Guofan1,3,4
2017-06-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume71Pages:82-87
SubtypeArticle
AbstractInterferon regulatory factors (IRFs) are transcription factors that play important roles in immune defense, stress response, hematopoietic differentiation, and cell apoptosis. IRFs of invertebrate organisms and their functions remain largely unexplored. In the present study, for the first time new IRFs (BpIRF2 and MmIRF2) were identified in the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus. The open reading frame of BpIRF2 and MmIRF2 encoded putative proteins of 354 and 348 amino acids, respectively. Comparison and phylogenetic analysis revealed that both IRF2 proteins were new identified invertebrate IRF molecular. As transcriptional factors, both BpIRF2 and MmIRF2 could activate the interferon-stimulated response element-containing promoter and BpIRF2 could interact with itself. Moreover, both BpIRF2 and MmIRF2 were localized to the cytoplasm and nucleus. Collectively, these results demonstrated that IRF2 proteins might be crucial in the innate immunity of deep-sea and shallow-water mussels. (C) 2017 Published by Elsevier Ltd.
KeywordIrf2 Deep-sea Mussel Isre Innate Immunity
DOI10.1016/j.dci.2017.01.015
Indexed BySCI
Language英语
WOS IDWOS:000397834800009
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136726
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
5.Chinese Acad Sci, Dept Marine Organism Taxon & Phylogeny, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Huang, Baoyu,Meng, Jie,Yang, Mei,et al. Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,71:82-87.
APA Huang, Baoyu.,Meng, Jie.,Yang, Mei.,Xu, Fei.,Li, Xinzheng.,...&Zhang, Guofan.(2017).Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,71,82-87.
MLA Huang, Baoyu,et al."Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 71(2017):82-87.
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