Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain

doi:10.2174/1566523217666161118165710

IOCAS-IR > 实验海洋生物学重点实验室

	Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain
	Tong, Hsin-I 1,3; Kang, Wen 1,2; Zhou, Guangzhou 1,4; Liu, Min 1,5; Shi, Yingli1,6 ; Lu, Yuanan 1
	2016
发表期刊	CURRENT GENE THERAPY
卷号	16 期号:6 页码:401-409
文章类型	Article
摘要	Objective: This study was aimed to explore the potential of a non-invasive monocytes-based delivery system to transport therapeutic genes into the diseased brain. The study was conducted by first establishing the optimized conditions for lentiviral vector (LV)-mediated gene transfer into freshly isolated monocytes, followed by investigating the inflamed-brain homing efficiency and in vivo cell-mediated transgene expression by carrier monocytes in a mouse model with acute sub-regional neuroinflammation.
关键词	Monocyte Non-invasive Delivery Cell-based Delivery System Gene Therapy Brain Neuroinflammation
DOI	10.2174/1566523217666161118165710
收录类别	SCI
语种	英语
WOS记录号	WOS:000399786700004
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/136712
专题	实验海洋生物学重点实验室
作者单位	1.Univ Hawaii Manoa, Off Publ Hlth Studies, Honolulu, HI 96822 USA 2.Fourth Mil Med Univ, Tangdu Hosp, Dept Infect Dis, Xian, Shaanxi, Peoples R China 3.Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA 4.Henan Univ Technol, Coll Bioengn, Zhengzhou, Henan, Peoples R China 5.Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 1, Dept Infect Dis, Xian, Shaanxi, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,et al. Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain[J]. CURRENT GENE THERAPY,2016,16(6):401-409.
APA	Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,Liu, Min,Shi, Yingli,&Lu, Yuanan.(2016).Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain.CURRENT GENE THERAPY,16(6),401-409.
MLA	Tong, Hsin-I,et al."Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain".CURRENT GENE THERAPY 16.6(2016):401-409.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
Evaluation on Monocy（3210KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览