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Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain
Tong, Hsin-I1,3; Kang, Wen1,2; Zhou, Guangzhou1,4; Liu, Min1,5; Shi, Yingli1,6; Lu, Yuanan1
2016
Source PublicationCURRENT GENE THERAPY
Volume16Issue:6Pages:401-409
SubtypeArticle
AbstractObjective: This study was aimed to explore the potential of a non-invasive monocytes-based delivery system to transport therapeutic genes into the diseased brain. The study was conducted by first establishing the optimized conditions for lentiviral vector (LV)-mediated gene transfer into freshly isolated monocytes, followed by investigating the inflamed-brain homing efficiency and in vivo cell-mediated transgene expression by carrier monocytes in a mouse model with acute sub-regional neuroinflammation.
KeywordMonocyte Non-invasive Delivery Cell-based Delivery System Gene Therapy Brain Neuroinflammation
DOI10.2174/1566523217666161118165710
Indexed BySCI
Language英语
WOS IDWOS:000399786700004
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136712
Collection实验海洋生物学重点实验室
Affiliation1.Univ Hawaii Manoa, Off Publ Hlth Studies, Honolulu, HI 96822 USA
2.Fourth Mil Med Univ, Tangdu Hosp, Dept Infect Dis, Xian, Shaanxi, Peoples R China
3.Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA
4.Henan Univ Technol, Coll Bioengn, Zhengzhou, Henan, Peoples R China
5.Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 1, Dept Infect Dis, Xian, Shaanxi, Peoples R China
6.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,et al. Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain[J]. CURRENT GENE THERAPY,2016,16(6):401-409.
APA Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,Liu, Min,Shi, Yingli,&Lu, Yuanan.(2016).Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain.CURRENT GENE THERAPY,16(6),401-409.
MLA Tong, Hsin-I,et al."Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain".CURRENT GENE THERAPY 16.6(2016):401-409.
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