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Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii
Yue, Yang1,2; Yu, Huahua1; Li, Rongfeng1; Xing, Ronge1; Liu, Song1; Li, Kecheng1; Wang, Xueqin1; Chen, Xiaolin1; Li, Pengcheng1
2017
Source PublicationTOXICON
Volume125Pages:1-12
SubtypeArticle
AbstractJellyfish envenomations are emerging as an important public health concern occurred worldwide. In China, the situation is getting worse with numerous people stung by jellyfish Nemopilema nomurai (N. nomurai) and Cyanea nozakii (C. nozakii) in the summer. However, the proteinaceous mixtures in nematocysts responsible for the symptoms of jellyfish stings were scarcely characterized and understood in view of enzymatic constituents and toxicity. In the present study, enzymatic properties of jellyfish N. nomurai and C. nozakii nematocyst venom were analyzed biochemically and kinetically. The current data revealed that N. nomurai and C. nozakii nematocyst venom exhibited various enzymatic activities, of which metalloproteinases activity and PLA(2)s-like activity were predominant. Moreover, the catalytic activities of metalloproteinases and PLA(2)s-like were dependent on different physiochemical conditions such as temperature, pH and divalent ions. Kinetic profiling revealed their catalytic behaviors fitted the Michaelis-Menten equation under specific conditions. Findings suggested jellyfish nematocyst venom possessed diverse enzymatic constituents, which may underlie the extensively characterized bioactivities of jellyfish venom and human envenomations. Hence, our study will contribute to understanding the enzymatic constituents and toxicity of jellyfish nematocyst venom and may afford potential therapeutic targets for developing drugs for jellyfish stings. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordJellyfish Venom Enzymatic Toxins Enzyme Kinetics Metalloproteinase Nemopilema Nomurai Cyanea Nozakii
DOI10.1016/j.toxicon.2016.11.005
Indexed BySCI
Language英语
WOS IDWOS:000392895800001
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136307
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
海洋环境工程技术研究发展中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yue, Yang,Yu, Huahua,Li, Rongfeng,et al. Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii[J]. TOXICON,2017,125:1-12.
APA Yue, Yang.,Yu, Huahua.,Li, Rongfeng.,Xing, Ronge.,Liu, Song.,...&Li, Pengcheng.(2017).Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii.TOXICON,125,1-12.
MLA Yue, Yang,et al."Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii".TOXICON 125(2017):1-12.
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