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Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis)
Long, Hao1,2; Sun, Li1,2
2016-10-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号57页码:340-349
文章类型Article
摘要Caspases are a family of proteases involved in many important biological processes including apoptosis and inflammation. In this study, we analyzed in a comparative manner the expression patterns and immune effects of four different types of caspases, i.e. caspase-1 (CsCas1), caspase-2 (CsCas2), caspase-3 (CsCas3), and caspase-9 (CsCas9), from the teleost fish tongue sole (Cynoglossus semilaevis). CsCas1, CsCas2, CsCas3, and CsCas9 share 35.4%-58.5%, 61.2%-75.3%, 523%-65.6%, and 63.0%-76.2% overall sequence identities, respectively, with their counterparts in teleost species. CsCas1, CsCas2, CsCas3, and CsCas9 possess the caspase domain and catalytic site conserved in known caspases. The expressions of the four caspases were detected in a wide range of tissues, however, the expression levels varied between different tissues and caspases. Following bacterial infection, the expressions of the four caspases were upregulated or downregulated to significant extents in a time- and tissue-dependent manner. In vivo analysis showed that overexpression of each of the caspases in tongue sole significantly enhanced the ability of the fish to resist bacterial dissemination in and colonization of tissues. These results indicate an involvement of fish caspases in bacteria-induced immune response and demonstrate for the first time that caspase-1, 2, 3, and 9 are essential to the optimal defense against bacterial infection in fish. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Caspase Cynoglossus Semilaevis Antibacterial Overexpression Apoptosis Edwardsiella Tarda
DOI10.1016/j.fsi.2016.08.047
收录类别SCI
语种英语
WOS记录号WOS:000385327100037
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136157
专题实验海洋生物学重点实验室
研究生部
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
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Long, Hao,Sun, Li. Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis)[J]. FISH & SHELLFISH IMMUNOLOGY,2016,57:340-349.
APA Long, Hao,&Sun, Li.(2016).Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis).FISH & SHELLFISH IMMUNOLOGY,57,340-349.
MLA Long, Hao,et al."Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis)".FISH & SHELLFISH IMMUNOLOGY 57(2016):340-349.
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