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Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection
Li, Xue-peng1,2,3; Sun, Li1,2
2016-04-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号51页码:321-328
文章类型Article
摘要Toll-like receptor (TLR) 2 is a member of the TLR family that plays a pivotal role in innate immunity. In mammals, TLR2 is known to recognize specific microbial structures and trigger MyD88-dependent signaling to induce various cytokine responses. In this study, we examined the expression and function of the tongue sole Cynoglossus semilaevis TLR2, CsTLR2. CsTLR2 is composed of 898 amino acid residues and shares 25.6%-273% overall sequence identities with known teleost TLR2. CsTLR2 is a transmembrane protein with a toll/interleukin-1 receptor domain and eight leucine-rich repeats. Expression of CsTLR2 occurred in multiple tissues and was upregulated during bacterial infection. Stimulation of the CsTLR2 pathway led to enhanced expression of MyD88-dependent signaling molecules. Recombinant CsTLR2 (rCsTLR2) corresponding to the extracellular region was able to bind to a wide range of bacteria. Under both in vitro and in vivo conditions, rCsTLR2 significantly reduced bacterial infection. These observations add new insights into the signaling and function of teleost TLR2. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Toll-like Receptor Cynoglossus Semilaevis Myd88 Bacterial Infection
DOI10.1016/j.fsi.2016.03.001
收录类别SCI
语种英语
WOS记录号WOS:000374617700035
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/131051
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Li, Xue-peng,Sun, Li. Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2016,51:321-328.
APA Li, Xue-peng,&Sun, Li.(2016).Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection.FISH & SHELLFISH IMMUNOLOGY,51,321-328.
MLA Li, Xue-peng,et al."Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection".FISH & SHELLFISH IMMUNOLOGY 51(2016):321-328.
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