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Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica
Zhang Wenjing1,2; Sun Delin3; Zhao Xia4; Jin Weihua1; Wang Jing1; Zhang Quanbin1
2016
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
Volume34Issue:1Pages:177-185
SubtypeArticle
AbstractA rapid, sensitive and reproducible high performance liquid chromatography (HPLC) method with post-column fluorescence derivatization has been developed to determine the amount of low-molecular-weight sulfated polysaccharide (GFS) in vivo. The metabolism of GFS has been shown to fit a two component model following its administration by intravenous injection, and its pharmacokinetic parameters were determined to be as follows: half-time of distribution phase (t (1/2 alpha))=11.24 +/- 2.93 min, half-time of elimination phase (t (1/2 beta))=98.20 +/- 25.78 min, maximum concentration (C (max))=110.53 mu g/mL and peak time (T (max))=5 min. The pharmacokinetic behavior of GFS was also investigated following intragastric administration. However, the concentration of GFS found in serum was too low for detection, and GFS could only be detected for up to 2 h after intragastric administration (200 mg/kg body weight). Thus, the bioavailability of GFS was low following intragastric administration because of the metabolism of GFS. In conclusion, HPLC with postcolumn derivatization could be used for quantitative microanalysis and pharmacokinetic studies to determine the presence of polysaccharides in the serum following intravenous injection.
KeywordSulfated Polysaccharide Hplc Post-column Derivatization Microanalysis Pharmacokinetics
DOI10.1007/s00343-015-4273-9
Indexed BySCI
Language英语
WOS IDWOS:000370345300018
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/112475
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Heze Junxinyuan Food Co, Heze 274415, Peoples R China
4.Ocean Univ China, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang Wenjing,Sun Delin,Zhao Xia,et al. Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(1):177-185.
APA Zhang Wenjing,Sun Delin,Zhao Xia,Jin Weihua,Wang Jing,&Zhang Quanbin.(2016).Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(1),177-185.
MLA Zhang Wenjing,et al."Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.1(2016):177-185.
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