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Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica
Zhang Wenjing1,2; Sun Delin3; Zhao Xia4; Jin Weihua1; Wang Jing1; Zhang Quanbin1
2016
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
卷号34期号:1页码:177-185
文章类型Article
摘要A rapid, sensitive and reproducible high performance liquid chromatography (HPLC) method with post-column fluorescence derivatization has been developed to determine the amount of low-molecular-weight sulfated polysaccharide (GFS) in vivo. The metabolism of GFS has been shown to fit a two component model following its administration by intravenous injection, and its pharmacokinetic parameters were determined to be as follows: half-time of distribution phase (t (1/2 alpha))=11.24 +/- 2.93 min, half-time of elimination phase (t (1/2 beta))=98.20 +/- 25.78 min, maximum concentration (C (max))=110.53 mu g/mL and peak time (T (max))=5 min. The pharmacokinetic behavior of GFS was also investigated following intragastric administration. However, the concentration of GFS found in serum was too low for detection, and GFS could only be detected for up to 2 h after intragastric administration (200 mg/kg body weight). Thus, the bioavailability of GFS was low following intragastric administration because of the metabolism of GFS. In conclusion, HPLC with postcolumn derivatization could be used for quantitative microanalysis and pharmacokinetic studies to determine the presence of polysaccharides in the serum following intravenous injection.
关键词Sulfated Polysaccharide Hplc Post-column Derivatization Microanalysis Pharmacokinetics
DOI10.1007/s00343-015-4273-9
收录类别SCI
语种英语
WOS记录号WOS:000370345300018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/112475
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Heze Junxinyuan Food Co, Heze 274415, Peoples R China
4.Ocean Univ China, Qingdao 266071, Peoples R China
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GB/T 7714
Zhang Wenjing,Sun Delin,Zhao Xia,et al. Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2016,34(1):177-185.
APA Zhang Wenjing,Sun Delin,Zhao Xia,Jin Weihua,Wang Jing,&Zhang Quanbin.(2016).Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,34(1),177-185.
MLA Zhang Wenjing,et al."Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 34.1(2016):177-185.
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