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Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster
Huang, Baoyu1; Zhang, Linlin1; Du, Yishuai1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
2016
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号48页码:12-19
文章类型Article
摘要Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial adaptors, playing vital roles in mediating signal transduction in immune signaling pathways, including RIG-I-like receptor (RLR) signaling pathway. In the present study, a new TRAF family member (CgTRAF2) was identified in the Pacific oyster, Crassostrea gigas. Comparison and phylogenetic analysis revealed that CgTRAF2 could be a new member of the invertebrate TRAF2 family. Quantitative real-time PCR revealed that CgTRAF2 mRNA was highly expressed in the digestive gland, gills, and hemocytes, and it was significantly up regulated after Vibrio alginolyticus and ostreid herpesvirus 1 (OsHV-1) challenge. The CgTRAF2 mRNA expression profile in different developmental stages of oyster larvae suggested that CgTRAF2 could function in early larval development. CgTRAF2 mRNA expression pattern, after the silence of CgMAVS (Mitochondrial Antiviral Signaling) -like, indicated that CgTRAF2 might function downstream of CgMAVS-like. Moreover, the subcellular localization analysis revealed that CgTRAF2 was localized in cytoplasm, and it may play predominately important roles in signal transduction. Collectively, these results demonstrated that CgTRAF2 might play important roles in the innate immunity and larval development of the Pacific oyster. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Pacific Oyster Crassostrea Gigas Traf2 Innate Immunity Mavs
DOI10.1016/j.fsi.2015.11.027
收录类别SCI
语种英语
WOS记录号WOS:000368953000002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/112436
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Huang, Baoyu,Zhang, Linlin,Du, Yishuai,et al. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2016,48:12-19.
APA Huang, Baoyu,Zhang, Linlin,Du, Yishuai,Li, Li,Tang, Xueying,&Zhang, Guofan.(2016).Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,48,12-19.
MLA Huang, Baoyu,et al."Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 48(2016):12-19.
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