IOCAS-IR  > 海洋生物技术研发中心
Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster
Huang, Baoyu1; Zhang, Linlin1; Du, Yishuai1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
2016
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume48Pages:12-19
SubtypeArticle
AbstractTumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial adaptors, playing vital roles in mediating signal transduction in immune signaling pathways, including RIG-I-like receptor (RLR) signaling pathway. In the present study, a new TRAF family member (CgTRAF2) was identified in the Pacific oyster, Crassostrea gigas. Comparison and phylogenetic analysis revealed that CgTRAF2 could be a new member of the invertebrate TRAF2 family. Quantitative real-time PCR revealed that CgTRAF2 mRNA was highly expressed in the digestive gland, gills, and hemocytes, and it was significantly up regulated after Vibrio alginolyticus and ostreid herpesvirus 1 (OsHV-1) challenge. The CgTRAF2 mRNA expression profile in different developmental stages of oyster larvae suggested that CgTRAF2 could function in early larval development. CgTRAF2 mRNA expression pattern, after the silence of CgMAVS (Mitochondrial Antiviral Signaling) -like, indicated that CgTRAF2 might function downstream of CgMAVS-like. Moreover, the subcellular localization analysis revealed that CgTRAF2 was localized in cytoplasm, and it may play predominately important roles in signal transduction. Collectively, these results demonstrated that CgTRAF2 might play important roles in the innate immunity and larval development of the Pacific oyster. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordPacific Oyster Crassostrea Gigas Traf2 Innate Immunity Mavs
DOI10.1016/j.fsi.2015.11.027
Indexed BySCI
Language英语
WOS IDWOS:000368953000002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/112436
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Baoyu,Zhang, Linlin,Du, Yishuai,et al. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2016,48:12-19.
APA Huang, Baoyu,Zhang, Linlin,Du, Yishuai,Li, Li,Tang, Xueying,&Zhang, Guofan.(2016).Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,48,12-19.
MLA Huang, Baoyu,et al."Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 48(2016):12-19.
Files in This Item:
File Name/Size DocType Version Access License
Molecular characteri(1280KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Baoyu]'s Articles
[Zhang, Linlin]'s Articles
[Du, Yishuai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Baoyu]'s Articles
[Zhang, Linlin]'s Articles
[Du, Yishuai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Baoyu]'s Articles
[Zhang, Linlin]'s Articles
[Du, Yishuai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.