| Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster | |
Huang, Baoyu1 ; Zhang, Linlin1; Du, Yishuai1; Li, Li1; Tang, Xueying1,2; Zhang, Guofan1
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| 2016 | |
| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| 卷号 | 48页码:12-19 |
| 文章类型 | Article |
| 摘要 | Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial adaptors, playing vital roles in mediating signal transduction in immune signaling pathways, including RIG-I-like receptor (RLR) signaling pathway. In the present study, a new TRAF family member (CgTRAF2) was identified in the Pacific oyster, Crassostrea gigas. Comparison and phylogenetic analysis revealed that CgTRAF2 could be a new member of the invertebrate TRAF2 family. Quantitative real-time PCR revealed that CgTRAF2 mRNA was highly expressed in the digestive gland, gills, and hemocytes, and it was significantly up regulated after Vibrio alginolyticus and ostreid herpesvirus 1 (OsHV-1) challenge. The CgTRAF2 mRNA expression profile in different developmental stages of oyster larvae suggested that CgTRAF2 could function in early larval development. CgTRAF2 mRNA expression pattern, after the silence of CgMAVS (Mitochondrial Antiviral Signaling) -like, indicated that CgTRAF2 might function downstream of CgMAVS-like. Moreover, the subcellular localization analysis revealed that CgTRAF2 was localized in cytoplasm, and it may play predominately important roles in signal transduction. Collectively, these results demonstrated that CgTRAF2 might play important roles in the innate immunity and larval development of the Pacific oyster. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Pacific Oyster Crassostrea Gigas Traf2 Innate Immunity Mavs |
| DOI | 10.1016/j.fsi.2015.11.027 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000368953000002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/112436 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Huang, Baoyu,Zhang, Linlin,Du, Yishuai,et al. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2016,48:12-19. |
| APA | Huang, Baoyu,Zhang, Linlin,Du, Yishuai,Li, Li,Tang, Xueying,&Zhang, Guofan.(2016).Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,48,12-19. |
| MLA | Huang, Baoyu,et al."Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 48(2016):12-19. |
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| Molecular characteri（1280KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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