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Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
Adobe PDF(824Kb)  |  收藏  |  浏览/下载：267/0  |  提交时间：2019/08/21
Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 145-157
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Li, Xiang-qian;  Guo, Chuan-long;  Guo, Shu-ju;  Shi, Da-Yong
Adobe PDF(1523Kb)  |  收藏  |  浏览/下载：274/0  |  提交时间：2019/08/21
DPP-4  Inhibitors  Analogs  Physico-chemical properties  SARs  Type 2 diabetes  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  收藏  |  浏览/下载：304/0  |  提交时间：2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer  
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation 期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:  Wang, Li-Jun;  Guo, Chuan-Long;  Li, Xiang-Qian;  Wang, Shuai-Yu;  Jiang, Bo;  Zhao, Yue;  Luo, Jiao;  Xu, Kuo;  Liu, Hua;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
收藏  |  浏览/下载：272/0  |  提交时间：2019/07/15
bromophenol hybrids  anticancer  structure-activity relationships  ROS  apoptotic pathway  
Sesquiterpenes from Laurencia similis 期刊论文
MOLECULES, 2009, 卷号: 14, 期号: 5, 页码: 1889-1897
作者:  Su, Hua;  Shi, Da-Yong;  Li, Jing;  Guo, Shu-Ju;  Li, Li-Li;  Yuan, Zhao-Hui;  Zhu, Xiao-Bin;  Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Adobe PDF(193Kb)  |  收藏  |  浏览/下载：254/0  |  提交时间：2010/11/18
Laurencia Similis  Sesquiterpenes  Cytotoxic Assay  
Two new bromoindoles from red alga Laurencia similis 期刊论文
CHINESE CHEMICAL LETTERS, 2009, 卷号: 20, 期号: 4, 页码: 456-458
作者:  Su, Hua;  Yuan, Zhao Hui;  Li, Jing;  Guo, Shu Ju;  Deng, Li Ping;  Han, Li Jun;  Bin Zhu, Xiao;  Shi, Da Yong
Adobe PDF(145Kb)  |  收藏  |  浏览/下载：254/0  |  提交时间：2010/12/22
Laurencia Similis  Bromoindole Alkaloid  2  2 '  3  5  5-dibromo-1-methylindole  5 '  6  6 '-sixibromo-3  3 '-bi-1h-indole  
Sesquiterpenes from the Marine Red Alga Laurencia saitoi 期刊论文
HELVETICA CHIMICA ACTA, 2009, 卷号: 92, 期号: 7, 页码: 1291-1297
作者:  Su, Hua;  Yuan, Zhao-Hui;  Li, Jing;  Guo, Shu-Ju;  Deng, Li-Ping;  Han, Li-Jun;  Zhu, Xiao-Bin;  Shi, Da-Yong
Adobe PDF(175Kb)  |  收藏  |  浏览/下载：292/2  |  提交时间：2010/12/22
Derivatives  
Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor 期刊论文
CHINESE CHEMICAL LETTERS, 2008, 卷号: 19, 期号: 11, 页码: 1290-1292
作者:  Li, Jing;  Guo, Shu Ju;  Su, Hua;  Han, Li Jun;  shi, Da Yong
Adobe PDF(181Kb)  |  收藏  |  浏览/下载：282/0  |  提交时间：2010/12/24
Bromophenol  Ptp1b Inhibitor  Bis-(2  Total Synthesis  3-dibromo-4  5-dihydroxyphenyl)-methane