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Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：289/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study 期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:  Li, Xiuxue;  Wang, Lijun;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Chao;  Zhang, Jiajia;  Shi, Dayong
Adobe PDF(579Kb)  |  收藏  |  浏览/下载：155/0  |  提交时间：2020/09/23
Novel compound  Quantitation  UHPLC-TOF-MS  Pharmacokinetics  
Draft genomes of two Atlantic bay scallop subspecies Argopecten irradians irradians and A. i. concentricus 期刊论文
SCIENTIFIC DATA, 2020, 卷号: 7, 期号: 1, 页码: 8
作者:  Liu, Xiao;  Li, Chao;  Chen, Min;  Liu, Bo;  Yan, Xiaojun;  Ning, Junhao;  Ma, Bin;  Liu, Guilong;  Zhong, Zhaoshan;  Jia, Yanglei;  Shi, Qiong;  Wang, Chunde
Adobe PDF(2043Kb)  |  收藏  |  浏览/下载：161/0  |  提交时间：2020/09/23
Structural and Bioactive Studies of Halogenated Constituents from Sponges 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 14, 页码: 2335-2360
作者:  Li, Chao;  Shi, Dayong
收藏  |  浏览/下载：201/0  |  提交时间：2020/09/24
Halogenated  sponges  marine  isolate  constitutes  activity  
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
作者:  Xu, Qi;  Wu, Ning;  Li, Xiangqian;  Guo, Chuanlong;  Li, Chao;  Jiang, Bo;  Wang, Huaizhi;  Shi, Dayong
Adobe PDF(3632Kb)  |  收藏  |  浏览/下载：287/0  |  提交时间：2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：323/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice 期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
作者:  Li, Chao;  Luo, Jiao;  Guo, Shuju;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Xiangqian;  Xu, Qi;  Shi, Dayong
收藏  |  浏览/下载：311/0  |  提交时间：2019/08/28
type 2 diabetes mellitus  protein tyrosine phosphatase 1B  insulin resistance  hypoglycemic activity  dyslipidemia  
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Adobe PDF(2321Kb)  |  收藏  |  浏览/下载：189/0  |  提交时间：2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
作者:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
收藏  |  浏览/下载：298/0  |  提交时间：2019/08/28
brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
Carbon pools and fluxes in the China Seas and adjacent oceans 期刊论文
SCIENCE CHINA-EARTH SCIENCES, 2018, 卷号: 61, 期号: 11, 页码: 1535-1563
作者:  Jiao, Nianzhi;  Liang, Yantao;  Zhang, Yongyu;  Liu, Jihua;  Zhang, Yao;  Zhang, Rui;  Zhao, Meixun;  Dai, Minhan;  Zhai, Weidong;  Gao, Kunshan;  Song, Jinming;  Yuan, Dongliang;  Li, Chao;  Lin, Guanghui;  Huang, Xiaoping;  Yan, Hongqiang;  Hu, Limin;  Zhang, Zenghu;  Wang, Long;  Cao, Chunjie;  Luo, Yawei;  Luo, Tingwei;  Wang, Nannan;  Dang, Hongyue;  Wang, Dongxiao;  Zhang, Si
Adobe PDF(9420Kb)  |  收藏  |  浏览/下载：282/0  |  提交时间：2019/05/15
China Seas  "Source" or "sink" of CO2  Carbon pool  Carbon flux  Biological pump  Microbial carbon pump