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Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：297/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study 期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:  Li, Xiuxue;  Wang, Lijun;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Chao;  Zhang, Jiajia;  Shi, Dayong
Adobe PDF(579Kb)  |  收藏  |  浏览/下载：161/0  |  提交时间：2020/09/23
Novel compound  Quantitation  UHPLC-TOF-MS  Pharmacokinetics  
Structural and Bioactive Studies of Halogenated Constituents from Sponges 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 14, 页码: 2335-2360
作者:  Li, Chao;  Shi, Dayong
收藏  |  浏览/下载：204/0  |  提交时间：2020/09/24
Halogenated  sponges  marine  isolate  constitutes  activity  
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：329/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
作者:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
收藏  |  浏览/下载：306/0  |  提交时间：2019/08/28
brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
Halogenated Compounds from Corals: Chemical Diversity and Biological Activities 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 15, 页码: 1204-1218
作者:  Zhang, Yuanyuan;  Liu, Junhong;  Shi, Dayong;  Li, Zheng
收藏  |  浏览/下载：124/0  |  提交时间：2020/09/21
Marine  corals  metabolites  halogenated  bioactivity  chemical diversity  
Recent Advances in Transition-metal-catalyzed Halides Formation 期刊论文
CURRENT ORGANIC CHEMISTRY, 2018, 卷号: 22, 期号: 23, 页码: 2229-2255
作者:  Shi, Xiaolin;  Shi, Dayong
Adobe PDF(1243Kb)  |  收藏  |  浏览/下载：212/0  |  提交时间：2019/05/15
Catalysis  C-X bond  halides formation  halogenated  organohalides  palladium  transition metals