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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载:3/0  |  提交时间:2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Combined transcriptome and proteome analysis reveal the key physiological processes in seed germination stimulated by decreased salinity in the seagrass Zostera marina L. 期刊论文
BMC PLANT BIOLOGY, 2023, 卷号: 23, 期号: 1, 页码: 21
作者:  Zhang, Yu;  Yue, Shidong;  Liu, Mingjie;  Wang, Xinhua;  Xu, Shaochun;  Zhang, Xiaomei;  Zhou, Yi
Adobe PDF(2843Kb)  |  收藏  |  浏览/下载:1/0  |  提交时间:2024/04/07
Seagrass  Zostera marina L.  Seed germination  Low-salinity stimulation  Transcriptome and proteome  
Molecular evidence for the adaptive evolution in euryhaline bivalves 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(7600Kb)  |  收藏  |  浏览/下载:4/1  |  提交时间:2024/04/07
Adaptive evolution  Euryhaline bivalves  Osmoregulation  Energy metabolism  ROS scavenging  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载:146/1  |  提交时间:2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
Expansion of photoreception-related gene families may drive ecological adaptation of the dominant diatom species Skeletonema marinoi 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 897, 页码: 12
作者:  Liu, Shuya;  Xu, Qing;  Chen, Nansheng
Adobe PDF(4070Kb)  |  收藏  |  浏览/下载:52/0  |  提交时间:2023/12/13
Comparative genomics  Skeletonema marinoi  Coastal dominant diatom  Photoreception-related gene families  Chromosome-level genome  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载:4/1  |  提交时间:2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber 期刊论文
ENVIRONMENTAL POLLUTION, 2023, 卷号: 330, 页码: 9
作者:  Huo, Da;  Zhang, Libin;  Yang, Hongsheng;  Sun, Lina
收藏  |  浏览/下载:32/0  |  提交时间:2023/12/13
Hypoxic stress  Environmental stress  Apostichopus japonicus  Metabolome  Amino acids  
海水酸化和甲基汞胁迫下文蛤 Meretrix petechialis (Lamarck) 的抗氧化防御和免疫应答 学位论文
, 中国科学院海洋研究所: 中国科学院大学, 2023
作者:  杨建朋
Adobe PDF(3019Kb)  |  收藏  |  浏览/下载:70/0  |  提交时间:2023/06/18
海水酸化,重金属,生理响应,海洋贝类,生物标志物  
海洋酸化情景下褐牙鲆(Paralichthys olivaceus)仔、幼鱼对铜胁迫的抗氧化和解毒防御、离子调节与固有免疫响应 学位论文
, 北京: 中国科学院大学, 2023
作者:  肖子桃
Adobe PDF(8314Kb)  |  收藏  |  浏览/下载:102/0  |  提交时间:2023/06/16
海洋酸化    抗氧化和解毒  离子调节和固有免疫  海洋硬骨鱼类