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Isolation and Characterization of Fucoidans from Five Brown Algae and Evaluation of Their Antioxidant Activity 期刊论文
JOURNAL OF OCEAN UNIVERSITY OF CHINA, 2014, 卷号: 13, 期号: 5, 页码: 851-856
Authors:  Qu Guiyan;  Liu Xu;  Wang Dongfeng;  Yuan Yi;  Han Lijun;  Han, LJ (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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Fucoidans Composition  Antioxidant Property  Laminaria Japonica  Lessonia Nigrescens  Lessonia Trabeculata  Ascophyllum Mackaii  Ecklonia Maxima  
A study of neuroprotective and antioxidant activities of heteropolysaccharides from six Sargassum species 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2014, 卷号: 67, 页码: 336-342
Authors:  Jin, Weihua;  Zhang, Wenjing;  Wang, Jing;  Yao, Jianting;  Xie, Enyi;  Liu, Dongchao;  Duan, Delin;  Zhang, Quanbin;  Zhang, QB (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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Neuroprotective Activity  Antioxidant Activity  Sargassum  
The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy 期刊论文
MARINE DRUGS, 2014, 卷号: 12, 期号: 6, 页码: 3292-3306
Authors:  Wang, Jing;  Liu, Huaide;  Li, Ning;  Zhang, Quanbin;  Zhang, Hong;  Li, N (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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Sulfated Polysaccharide  Fucoidan  Diabetic Nephropathy  
一种从泡叶藻中提取制备低分子岩藻聚糖硫酸酯的方法 专利
专利类型: 发明, 专利号: CN201210424580.8, 申请日期: 2014-05-14, 公开日期: 2014-05-14
Inventors:  韩丽君;  袁毅;  郭书举;  曲桂艳;  刘旭
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一种从泡叶藻中提取制备低分子岩藻聚糖硫酸酯的方法  其特征在于:1)将泡叶藻原料于40‑60℃下浸泡提取在泡叶藻原料干藻重量6‑10倍的稀盐酸溶液中1.3‑4.8h  酸浸泡后的泡叶藻固体继续加入其体积3‑6倍的水溶液  稀酸浸泡液待用  搅拌浸泡4‑7h  2)将上层漂浮物调节至ph5.5‑6.5  保留上层漂浮物  收集水浸泡液  在经过滤或高速离心  将上述依次经稀酸和水浸泡后固态藻体采用纳米高压均质机进行细胞破碎  将稀酸浸泡和水浸泡液合并待用  收集过滤液a  破碎后进行离心分离收集上清液b  3)将上述合并液、过滤液a和上清液b混合均匀后进行超滤去除盐分  而后超滤浓缩至原料重量的1/2体积(v/w)  4)将上述岩藻聚糖硫酸酯粗干品加入其3‑5倍重量的蒸馏水中进行溶解  浓缩液进行醇沉淀  溶解后通过装有deae‑sepharose f.f.的阴离子交换树脂柱进行洗脱  沉淀物干燥  收集洗脱液透析后于55‑65℃低温浓缩并冷冻干燥获得  即为岩藻聚糖硫酸酯粗干品  即得到原藻重量1.5‑2.3%的岩藻聚糖硫酸酯。  
褐藻中酸性多糖的结构分析及神经保护活性研究 学位论文
, 北京: 中国科学院研究生院, 2014
Authors:  金维华
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酸性多糖  神经保护活性  结构分析  硫酸化岩藻聚糖  硫酸化半乳聚糖  硫酸化杂多糖  抗凝血活性  
海带褐藻多糖硫酸酯抗肾衰的机制研究 学位论文
, 北京: 中国科学院研究生院, 2014
Authors:  王雪妹
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褐藻多糖硫酸酯  大鼠肾小球系膜细胞  信号分子no  Tgf-β1  乙酰肝素酶  
Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats 期刊论文
LABORATORY INVESTIGATION, 2014, 卷号: 94, 期号: 4, 页码: 382-393
Authors:  Cui, Wentong;  Zheng, Yuanyuan;  Zhang, Quanbin;  Wang, Jing;  Wang, Limin;  Yang, Wenzhe;  Guo, Chenyang;  Gao, Weidong;  Wang, Xiaomin;  Luo, Dali;  Luo, DL (reprint author), Capital Med Univ, Dept Pharmacol, St Youanmenwai,10 Xitoutiao, Beijing 100069, Peoples R China.
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Diabetes  Endothelium-dependent Vasodilation  Endothelial Nitric Oxide Synthase  Low-molecular-weight Fucoidan  Nitric Oxide  
Characterization of laminaran and a highly sulfated polysaccharide from Sargassum fusiforme 期刊论文
CARBOHYDRATE RESEARCH, 2014, 卷号: 385, 页码: 58-64
Authors:  Jin, Weihua;  Zhang, Wenjing;  Wang, Jing;  Ren, Sumei;  Song, Ni;  Duan, Delin;  Zhang, Quanbin;  Zhang, QB (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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Esi-cid-ms/ms  Laminaran  Sargassum Fusiforme  Nmr  Sulfated Polysaccharide  
Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis 期刊论文
JOURNAL OF DIABETES RESEARCH, 2014, 页码: 420929
Authors:  Yu, Xinfeng;  Zhang, Quanbin;  Cui, Wentong;  Zeng, Zheng;  Yang, Wenzhe;  Zhang, Chao;  Zhao, Hongwei;  Gao, Weidong;  Wang, Xiaomin;  Luo, Dali;  Luo, DL (reprint author), Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Youanmenwai St,10 Xitoutiao, Beijing 100069, Peoples R China.
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