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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Transcriptomic analysis reveals the immune response mechanisms of sea cucumber Apostichopus japonicus under noise stress from offshore wind turbine 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 906, 页码: 11
作者:  Cheng, Xiaochen;  Zhang, Libin;  Gao, Zhaoming;  Li, Kehan;  Xu, Jialei;  Liu, Weijian;  Ru, Xiaoshang
收藏  |  浏览/下载:1/0  |  提交时间:2024/04/07
Offshore wind power  Underwater noise  Sea cucumber  Invertebrate  Transcriptome  Immune response  
Chromosome-level genome assembly of the deep-sea snail Phymorhynchus buccinoides provides insights into the adaptation to the cold seep habitat 期刊论文
BMC GENOMICS, 2023, 卷号: 24, 期号: 1, 页码: 16
作者:  Liu, Zhaoqun;  Huang, Yuting;  Chen, Hao;  Liu, Chang;  Wang, Minxiao;  Bian, Chao;  Wang, Lingling;  Song, Linsheng
Adobe PDF(5637Kb)  |  收藏  |  浏览/下载:1/0  |  提交时间:2024/04/07
Cold seep  Phymorhynchus buccinoides  Chromosome-level genome  Glutamate regulation  Olfactory/chemosensory  H2S detoxification  
Molecular evidence for the adaptive evolution in euryhaline bivalves 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(7600Kb)  |  收藏  |  浏览/下载:4/1  |  提交时间:2024/04/07
Adaptive evolution  Euryhaline bivalves  Osmoregulation  Energy metabolism  ROS scavenging  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载:139/1  |  提交时间:2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
Novel insights into toxin changes associated with the growth of Alexandrium pacificum: Revealing active toxin-secretion ability and toxin cell quota variation 期刊论文
HARMFUL ALGAE, 2023, 卷号: 129, 页码: 8
作者:  Song, Weijia;  Song, Xiuxian;  Chi, Lianbao;  Zhu, Jianan;  Cao, Xihua;  Yu, Zhiming
Adobe PDF(1811Kb)  |  收藏  |  浏览/下载:1/0  |  提交时间:2024/04/07
Alexandrium pacificum  Extracellular toxins  Toxin cell quota  Growth phases  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载:3/1  |  提交时间:2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
海水酸化和甲基汞胁迫下文蛤 Meretrix petechialis (Lamarck) 的抗氧化防御和免疫应答 学位论文
, 中国科学院海洋研究所: 中国科学院大学, 2023
作者:  杨建朋
Adobe PDF(3019Kb)  |  收藏  |  浏览/下载:69/0  |  提交时间:2023/06/18
海水酸化,重金属,生理响应,海洋贝类,生物标志物  
生物改性对粘土法治理有害藻华的增效机制研究 学位论文
理学博士, 中国科学院海洋研究所: 中国科学院大学, 2023
作者:  刘姗姗
Adobe PDF(6663Kb)  |  收藏  |  浏览/下载:82/2  |  提交时间:2023/06/15
芽孢杆菌  微生物改性粘土  有害藻华  脂肽  溶藻物质