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Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：285/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:  Guo, Chuanlong;  Wang, Lijun;  Zhao, Yue;  Jiang, Bo;  Luo, Jiao;  Shi, Dayong
Adobe PDF(2683Kb)  |  收藏  |  浏览/下载：230/0  |  提交时间：2019/08/28
bromophenol  apoptosis  autophagy  phosphoinositide 3-kinase  protein kinase B  mechanistic target of rapamycin signaling  reactive oxygen species  
Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2, 页码: 14
作者:  Liu, Hua;  Guo, Chuanlong;  Guo, Shuju;  Wang, Lijun;  Shi, Dayong
Adobe PDF(2843Kb)  |  收藏  |  浏览/下载：251/0  |  提交时间：2019/08/27
fluorescent probe  thiophenol  water samples  chalcone  living cells  
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
Adobe PDF(824Kb)  |  收藏  |  浏览/下载：267/0  |  提交时间：2019/08/21
Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 145-157
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Li, Xiang-qian;  Guo, Chuan-long;  Guo, Shu-ju;  Shi, Da-Yong
Adobe PDF(1523Kb)  |  收藏  |  浏览/下载：274/0  |  提交时间：2019/08/21
DPP-4  Inhibitors  Analogs  Physico-chemical properties  SARs  Type 2 diabetes  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  收藏  |  浏览/下载：304/0  |  提交时间：2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer  
Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 1, 页码: 140-153
作者:  Luo, Jiao;  Xu, Qi;  Jiang, Bo;  Zhang, Renshuai;  Jia, Xiaoling;  Li, Xiangqian;  Wang, Lijun;  Guo, Chuanlong;  Wu, Ning;  Shi, Dayong
Adobe PDF(2211Kb)  |  收藏  |  浏览/下载：239/0  |  提交时间：2019/08/20