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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载:4/0  |  提交时间:2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Combined transcriptome and proteome analysis reveal the key physiological processes in seed germination stimulated by decreased salinity in the seagrass Zostera marina L. 期刊论文
BMC PLANT BIOLOGY, 2023, 卷号: 23, 期号: 1, 页码: 21
作者:  Zhang, Yu;  Yue, Shidong;  Liu, Mingjie;  Wang, Xinhua;  Xu, Shaochun;  Zhang, Xiaomei;  Zhou, Yi
Adobe PDF(2843Kb)  |  收藏  |  浏览/下载:1/0  |  提交时间:2024/04/07
Seagrass  Zostera marina L.  Seed germination  Low-salinity stimulation  Transcriptome and proteome  
Molecular evidence for the adaptive evolution in euryhaline bivalves 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(7600Kb)  |  收藏  |  浏览/下载:5/1  |  提交时间:2024/04/07
Adaptive evolution  Euryhaline bivalves  Osmoregulation  Energy metabolism  ROS scavenging  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载:152/1  |  提交时间:2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
Expansion of photoreception-related gene families may drive ecological adaptation of the dominant diatom species Skeletonema marinoi 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 897, 页码: 12
作者:  Liu, Shuya;  Xu, Qing;  Chen, Nansheng
Adobe PDF(4070Kb)  |  收藏  |  浏览/下载:54/0  |  提交时间:2023/12/13
Comparative genomics  Skeletonema marinoi  Coastal dominant diatom  Photoreception-related gene families  Chromosome-level genome  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载:4/1  |  提交时间:2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber 期刊论文
ENVIRONMENTAL POLLUTION, 2023, 卷号: 330, 页码: 9
作者:  Huo, Da;  Zhang, Libin;  Yang, Hongsheng;  Sun, Lina
收藏  |  浏览/下载:32/0  |  提交时间:2023/12/13
Hypoxic stress  Environmental stress  Apostichopus japonicus  Metabolome  Amino acids  
Examination of the regulation of energy metabolism, antioxidant response, and ammonia detoxification in hard clam, Mercenaria mercenaria, under hypersalinity stress 期刊论文
AQUACULTURE, 2023, 卷号: 563, 页码: 11
作者:  Zhou, Cong;  Xu, Li;  Song, Hao;  Feng, Jie;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Youg-Reh;  Guo, Yong-Jun;  Li, Hai-Zhou;  Zhang, Tao
Adobe PDF(7096Kb)  |  收藏  |  浏览/下载:129/0  |  提交时间:2023/01/04
Hypersalinity  Osmoconformer  Metabolomics  Ammonia detoxification  Oxidative stress  
Integrated mRNA and miRNA transcriptomic analysis reveals the response of Rapana venosa to the metamorphic inducer (juvenile oysters) 期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2023, 卷号: 21, 页码: 702-715
作者:  Yang, Mei-Jie;  Song, Hao;  Shi, Pu;  Liang, Jian;  Hu, Zhi;  Zhou, Cong;  Hu, Peng-Peng;  Yu, Zheng-Lin;  Zhang, Tao
收藏  |  浏览/下载:85/0  |  提交时间:2023/12/13
Rapana venosa  Metamorphic inducer  mRNA  miRNA