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BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
作者:  Guo, Chuanlong;  Zhang, Fan;  Wu, Xiaochen;  Yu, Xuemin;  Wu, Xianggen;  Shi, Dayong;  Wang, Lijun
Adobe PDF(1767Kb)  |  收藏  |  浏览/下载：180/0  |  提交时间：2020/09/23
PARP-1 inhibitor  DNA double-strand breaks  HCC-1937  In vivo  Apoptosis  
Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae) 期刊论文
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2018, 卷号: 81, 页码: 42-44
作者:  Xu, Kuo;  Guo, Shuju;  Jia, Xiaoling;  Li, Xiang;  Shi, Dayong
Adobe PDF(298Kb)  |  收藏  |  浏览/下载：250/0  |  提交时间：2019/05/15
Leathesia nana  Chordariaceae  Bromophenol  Chemotaxonomy  PTP1B  
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
Adobe PDF(824Kb)  |  收藏  |  浏览/下载：267/0  |  提交时间：2019/08/21
Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
新型氟代PTP1B抑制剂的设计、合成及活性研究 学位论文
, 北京: 中国科学院大学, 2016
作者:  王保程
Adobe PDF(4845Kb)  |  收藏  |  浏览/下载：257/0  |  提交时间：2016/05/31
糖尿病  氟代化合物  Ptp1b抑制剂  计算机辅助药物设计  分子对接  
Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 2, 页码: 806-823
作者:  Wang, Li-Jun;  Wang, Shuai-Yu;  Jiang, Bo;  Wu, Ning;  Li, Xiang-Qian;  Wang, Bao-Cheng;  Luo, Jiao;  Yang, Meng;  Jin, Shui-Hua;  Shi, Da-Yong
Adobe PDF(1301Kb)  |  收藏  |  浏览/下载：240/0  |  提交时间：2015/06/15
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 64, 页码: 129-136
作者:  Jiang, Bo;  Guo, Shuju;  Shi, Dayong;  Guo, Chao;  Wang, Tao;  Shi, DY
Adobe PDF(1213Kb)  |  收藏  |  浏览/下载：310/1  |  提交时间：2014/07/17
Type 2 Diabetes Mellitus  Protein Tyrosine Phosphatase 1b  Bromophenol  Anti-diabetic Activities  
Halogenated Organic Molecules of Rhodomelaceae Origin: Chemistry and Biology 期刊论文
CHEMICAL REVIEWS, 2013, 卷号: 113, 期号: 5, 页码: 3632-3685
作者:  Wang, Bin-Gui;  Gloer, James B.;  Ji, Nai-Yun;  Zhao, Jian-Chun;  Wang, BG
Adobe PDF(9186Kb)  |  收藏  |  浏览/下载：288/0  |  提交时间：2014/07/17
栉孔扇贝免疫系统发生及母源免疫的初步研究 学位论文
: 中国科学院研究生院, 2013
作者:  岳峰
Adobe PDF(6959Kb)  |  收藏  |  浏览/下载：253/1  |  提交时间：2014/08/08
栉孔扇贝  个体发生  造血相关转录因子  免疫系统  母源免疫  
Bromophenol coupled with diketopiperazine from marine red alga Symphyocladia latiuscula 期刊论文
CHEMISTRY OF NATURAL COMPOUNDS, 2012, 卷号: 48, 期号: 4, 页码: 622-624
作者:  Xu, Xiuli;  Yin, Liyuan;  Fang, Nianqiao;  Fan, Xiao;  Song, Fuhang;  Xu, XL (reprint author), China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China.
Adobe PDF(65Kb)  |  收藏  |  浏览/下载：256/0  |  提交时间：2013/09/24
Symphyocladia Latiuscula  Bromophenol  Diketopiperazine  
Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2012, 卷号: 345, 期号: 6, 页码: 444-453
作者:  Jiang, Bo;  Shi, Dayong;  Cui, Yongchao;  Guo, Shuju;  Shi, DY (reprint author), Chinese Acad Sci, R&D Ctr Marine Biotechnol, Inst Oceanol, Qingdao, Peoples R China.
Adobe PDF(473Kb)  |  收藏  |  浏览/下载：255/1  |  提交时间：2013/09/24
Bromophenol  Protein Tyrosine Phosphatase 1b Inhibitor  Structure-activity Relationship  Type 2 Diabetes Mellitus