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两株深海来源真菌次级代谢产物及其生物活性研究 学位论文
学术型硕士, 中国科学院海洋研究所: 中国科学院大学, 2022
作者:  王雅楠
Adobe PDF(3784Kb)  |  收藏  |  浏览/下载：337/0  |  提交时间：2022/06/14
深海真菌  次级代谢产物  抑菌活性  绳状篮状菌  产黄青霉  
Naturally occurring ureidobromophenols with potent antioxidant activities from the marine red alga Rhodomela confervoides 期刊论文
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2021, 卷号: 56, 页码: 5
作者:  Li, Ke;  Li, Xiao-Ming;  Gloer, James B.;  Wang, Bin-Gui
Adobe PDF(541Kb)  |  收藏  |  浏览/下载：134/0  |  提交时间：2021/12/07
Marine red alga  Rhodomela confervoides  Ureidobromophenols  Antioxidant activity  
海洋溴酚化合物对肠道菌群的调节与益生菌降糖作用研究 学位论文
理学博士, 中国科学院海洋研究所: 中国科学院大学, 2021
作者:  张良
Adobe PDF(5745Kb)  |  收藏  |  浏览/下载：180/0  |  提交时间：2021/06/17
海洋溴酚化合物，肠道微生物，菌群结构，益生特性，降糖作用  
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:  Jiang, Bo;  Luo, Jiao;  Guo, Shuju;  Wang, Lijun
Adobe PDF(8153Kb)  |  收藏  |  浏览/下载：189/0  |  提交时间：2021/05/11
Type 2 diabetes mellitus  Protein tyrosine phosphatase 1B inhibitors  Thiazolidinedione  Insulin signaling  Anti-diabetic activities  
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：287/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes 期刊论文
MARINE DRUGS, 2020, 卷号: 18, 期号: 5, 页码: 13
作者:  Luo, Jiao;  Hou, Yufei;  Xie, Mengyue;  Ma, Wanli;  Shi, Dayong;  Jiang, Bo
Adobe PDF(2455Kb)  |  收藏  |  浏览/下载：247/0  |  提交时间：2020/09/25
CYC31  PTP1B inhibitor  insulin resistance  fatty acid oxidization  
Effects of a natural PTP1B inhibitor from Rhodomela confervoides on the amelioration of fatty acid-induced insulin resistance in hepatocytes and hyperglycaemia in STZ-induced diabetic rats 期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 6, 页码: 3429-3437
作者:  Guo, Shuju;  Wang, Lijun;  Chen, Dong;  Jiang, Bo
Adobe PDF(699Kb)  |  收藏  |  浏览/下载：260/0  |  提交时间：2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：321/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3051-3067
作者:  Guo, Chuanlong;  Wang, Lijun;  Li, Xinxue;  Wang, Shuaiyu;  Yu, Xuemin;  Xu, Kuo;  Zhao, Yue;  Luo, Jiao;  Li, Xiangqian;  Jiang, Bo;  Shi, Dayong
Adobe PDF(8824Kb)  |  收藏  |  浏览/下载：327/0  |  提交时间：2019/08/28
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Adobe PDF(2321Kb)  |  收藏  |  浏览/下载：187/0  |  提交时间：2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity