Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290 | |
Li, Xin1,2; Li, Xiao-Ming1; Zhang, Peng1,2; Wang, Bin-Gui1 | |
2015-12-02 | |
发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH |
卷号 | 17期号:12页码:1204-1212 |
文章类型 | Article |
摘要 | Ten secondary metabolites (1-10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Penicillium oxalicum EN-290. The structures of these compounds were elucidated on the basis of 1D and 2D NMR experiments and the absolute configuration of compound 2 was confirmed by electronic circular dichroism quantum calculations. Compound 1 showed potent activity against Staphylococcus aureus with an MIC value of 2.0g/ml, which is stronger than that of the positive control (chloromycetin, with an MIC 4.0g/ml). This compound also showed activity against harmful algal bloom causative species Nitzschia closterium with inhibition zones of 20, 16, and 10mm at 20, 10, and 5mg/ml, respectively. Interestingly, so far, this type of anti-HAB metabolites has only been found in the algal-derived isolate of P. oxalicum. It could probably be a defense of this fungus against environmental stress and threat of survival. |
关键词 | Marine Alga-derived Fungus Penicillium Oxalicum Secondary Metabolites Antibacterial Activity Anti-hab Activity |
DOI | 10.1080/10286020.2015.1117454 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000368454000012 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/95225 |
专题 | 实验海洋生物学重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China |
第一作者单位 | 实验海洋生物学重点实验室 |
推荐引用方式 GB/T 7714 | Li, Xin,Li, Xiao-Ming,Zhang, Peng,et al. A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1204-1212. |
APA | Li, Xin,Li, Xiao-Ming,Zhang, Peng,&Wang, Bin-Gui.(2015).A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1204-1212. |
MLA | Li, Xin,et al."A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1204-1212. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A new phenolic enami(1286KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
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