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A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290
Li, Xin1,2; Li, Xiao-Ming1; Zhang, Peng1,2; Wang, Bin-Gui1
2015-12-02
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷号17期号:12页码:1204-1212
文章类型Article
摘要Ten secondary metabolites (1-10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Penicillium oxalicum EN-290. The structures of these compounds were elucidated on the basis of 1D and 2D NMR experiments and the absolute configuration of compound 2 was confirmed by electronic circular dichroism quantum calculations. Compound 1 showed potent activity against Staphylococcus aureus with an MIC value of 2.0g/ml, which is stronger than that of the positive control (chloromycetin, with an MIC 4.0g/ml). This compound also showed activity against harmful algal bloom causative species Nitzschia closterium with inhibition zones of 20, 16, and 10mm at 20, 10, and 5mg/ml, respectively. Interestingly, so far, this type of anti-HAB metabolites has only been found in the algal-derived isolate of P. oxalicum. It could probably be a defense of this fungus against environmental stress and threat of survival.
关键词Marine Alga-derived Fungus Penicillium Oxalicum Secondary Metabolites Antibacterial Activity Anti-hab Activity
DOI10.1080/10286020.2015.1117454
收录类别SCI
语种英语
WOS记录号WOS:000368454000012
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/95225
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
第一作者单位实验海洋生物学重点实验室
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GB/T 7714
Li, Xin,Li, Xiao-Ming,Zhang, Peng,et al. A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1204-1212.
APA Li, Xin,Li, Xiao-Ming,Zhang, Peng,&Wang, Bin-Gui.(2015).A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1204-1212.
MLA Li, Xin,et al."A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1204-1212.
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