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A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290
Li, Xin1,2; Li, Xiao-Ming1; Zhang, Peng1,2; Wang, Bin-Gui1
2015-12-02
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume17Issue:12Pages:1204-1212
SubtypeArticle
AbstractTen secondary metabolites (1-10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Penicillium oxalicum EN-290. The structures of these compounds were elucidated on the basis of 1D and 2D NMR experiments and the absolute configuration of compound 2 was confirmed by electronic circular dichroism quantum calculations. Compound 1 showed potent activity against Staphylococcus aureus with an MIC value of 2.0g/ml, which is stronger than that of the positive control (chloromycetin, with an MIC 4.0g/ml). This compound also showed activity against harmful algal bloom causative species Nitzschia closterium with inhibition zones of 20, 16, and 10mm at 20, 10, and 5mg/ml, respectively. Interestingly, so far, this type of anti-HAB metabolites has only been found in the algal-derived isolate of P. oxalicum. It could probably be a defense of this fungus against environmental stress and threat of survival.
KeywordMarine Alga-derived Fungus Penicillium Oxalicum Secondary Metabolites Antibacterial Activity Anti-hab Activity
DOI10.1080/10286020.2015.1117454
Indexed BySCI
Language英语
WOS IDWOS:000368454000012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/95225
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xin,Li, Xiao-Ming,Zhang, Peng,et al. A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1204-1212.
APA Li, Xin,Li, Xiao-Ming,Zhang, Peng,&Wang, Bin-Gui.(2015).A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1204-1212.
MLA Li, Xin,et al."A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1204-1212.
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