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	CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection
	Wang, Ting1,2,3; Sun, Li1,2
	2016-02-01
发表期刊	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号	55期号:2016页码:12-20
文章类型	Article
摘要	Serum amyloid P component (SAP) is a member of the pentraxins family that plays important roles in innate immunity in vertebrates. In fish, the biological function of SAP is essentially unknown. In this study, we examined the expression and function of a SAP homologue (CsSAP) from tongue sole Cynoglossus semilaevis. CsSAP shares 46%-58% overall sequence identities with known fish SAP and was upregulated in expression by bacterial and viral infection. Recombinant CsSAP (rCsSAP) exhibited differential binding capacities to a wide range of Gram-positive and Gram-negative bacteria and promoted uptake of the bound bacteria by host phagocytes. When introduced in vivo, rCsSAP enhanced host resistance not only to bacterial infection but also to viral infection. Consistently, antibody blockage of CsSAP significantly weakened the ability of tongue sole to clear invading bacteria. These results provide the first evidence that fish SAP contributes significantly to both antibacterial and antiviral immunities. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Serum Amyloid p Component Cynoglossus Semilaevis Innate Immunity Antibacterial Antiviral
DOI	10.1016/j.dci.2015.10.002
收录类别	SCI
语种	英语
WOS记录号	WOS:000368382200002
引用统计	被引频次：37[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/95221
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Wang, Ting,Sun, Li. CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,55(2016):12-20.
APA	Wang, Ting,&Sun, Li.(2016).CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,55(2016),12-20.
MLA	Wang, Ting,et al."CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 55.2016(2016):12-20.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
a teleost serum amyl（1853KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览

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