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CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection
Wang, Ting1,2,3; Sun, Li1,2
2016-02-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号55期号:2016页码:12-20
文章类型Article
摘要Serum amyloid P component (SAP) is a member of the pentraxins family that plays important roles in innate immunity in vertebrates. In fish, the biological function of SAP is essentially unknown. In this study, we examined the expression and function of a SAP homologue (CsSAP) from tongue sole Cynoglossus semilaevis. CsSAP shares 46%-58% overall sequence identities with known fish SAP and was upregulated in expression by bacterial and viral infection. Recombinant CsSAP (rCsSAP) exhibited differential binding capacities to a wide range of Gram-positive and Gram-negative bacteria and promoted uptake of the bound bacteria by host phagocytes. When introduced in vivo, rCsSAP enhanced host resistance not only to bacterial infection but also to viral infection. Consistently, antibody blockage of CsSAP significantly weakened the ability of tongue sole to clear invading bacteria. These results provide the first evidence that fish SAP contributes significantly to both antibacterial and antiviral immunities. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Serum Amyloid p Component Cynoglossus Semilaevis Innate Immunity Antibacterial Antiviral
DOI10.1016/j.dci.2015.10.002
收录类别SCI
语种英语
WOS记录号WOS:000368382200002
引用统计
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/95221
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Wang, Ting,Sun, Li. CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,55(2016):12-20.
APA Wang, Ting,&Sun, Li.(2016).CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,55(2016),12-20.
MLA Wang, Ting,et al."CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 55.2016(2016):12-20.
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