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CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection
Wang, Ting1,2,3; Sun, Li1,2
2016-02-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume55Issue:2016Pages:12-20
SubtypeArticle
AbstractSerum amyloid P component (SAP) is a member of the pentraxins family that plays important roles in innate immunity in vertebrates. In fish, the biological function of SAP is essentially unknown. In this study, we examined the expression and function of a SAP homologue (CsSAP) from tongue sole Cynoglossus semilaevis. CsSAP shares 46%-58% overall sequence identities with known fish SAP and was upregulated in expression by bacterial and viral infection. Recombinant CsSAP (rCsSAP) exhibited differential binding capacities to a wide range of Gram-positive and Gram-negative bacteria and promoted uptake of the bound bacteria by host phagocytes. When introduced in vivo, rCsSAP enhanced host resistance not only to bacterial infection but also to viral infection. Consistently, antibody blockage of CsSAP significantly weakened the ability of tongue sole to clear invading bacteria. These results provide the first evidence that fish SAP contributes significantly to both antibacterial and antiviral immunities. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordSerum Amyloid p Component Cynoglossus Semilaevis Innate Immunity Antibacterial Antiviral
DOI10.1016/j.dci.2015.10.002
Indexed BySCI
Language英语
WOS IDWOS:000368382200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/95221
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
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Wang, Ting,Sun, Li. CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,55(2016):12-20.
APA Wang, Ting,&Sun, Li.(2016).CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,55(2016),12-20.
MLA Wang, Ting,et al."CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 55.2016(2016):12-20.
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