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Th17 master transcription factors ROR alpha and ROR gamma regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis
Chi, Heng1,2; Bogwald, Jarl3; Dalmo, Roy Ambli3; Zhang, Wenjie4; Hu, Yong-hua1,2
2016-02-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号55期号:2016页码:169-178
文章类型Article
摘要The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. In this study, we examined the regulatory properties of ROR alpha (CsROR alpha) and ROR gamma (CsROR gamma) in tongue sole (Cynoglossus semilaevis). CsROR alpha and CsROR gamma expression was detected in major lymphoid organs and altered to significant extents after bacterial and viral infection. CsROR alpha enhanced the activities of C5IL-17C, C5IL-17D, and C5IL-17F promoters, which contain CsROR alpha and CsROR gamma binding sites. CsROR gamma also upregulated the promoter activities of C5IL-17D and C5IL-17F but not CsIL-17C CsROR alpha and CsROR gamma proteins were detected in the nucleus, and overexpression of CsROR alpha in tongue sole significantly increased the expression of C5IL-17C, CsIL-17D, and C5IL-17F, whereas overexpression of CsROR gamma significantly increased the expression of CsIL-17C and CsIL-17F but no C5IL-17D. These results indicate that ROR alpha and ROR gamma in teleost regulate the expression of IL-17 members in different manners. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Ror Alpha Ror Gamma Il-17 Promoter Activity Cynoglossus Semilaevis
DOI10.1016/j.dci.2015.11.001
收录类别SCI
语种英语
WOS记录号WOS:000368382200019
引用统计
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/95214
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Tromso, Fac Biosci Fisheries & Econ, Norwegian Coll Fishery Sci, N-9037 Tromso, Norway
4.Guilin Univ Technol, Coll Environm Sci & Engn, Guilin 541004, Peoples R China
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Chi, Heng,Bogwald, Jarl,Dalmo, Roy Ambli,et al. Th17 master transcription factors ROR alpha and ROR gamma regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,55(2016):169-178.
APA Chi, Heng,Bogwald, Jarl,Dalmo, Roy Ambli,Zhang, Wenjie,&Hu, Yong-hua.(2016).Th17 master transcription factors ROR alpha and ROR gamma regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,55(2016),169-178.
MLA Chi, Heng,et al."Th17 master transcription factors ROR alpha and ROR gamma regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 55.2016(2016):169-178.
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