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Beta-chitosan extracted from Loligo Japonica for a potential use to inhibit Newcastle disease
He, Xiaofei1,2; Xing, Ronge1; Li, Kecheng1; Qin, Yukun1; Zou, Ping1,2; Liu, Song1; Yu, Huahua1; Li, Pengcheng1
2016
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume82Issue:2016Pages:614-620
SubtypeArticle
AbstractBeta-chitosan has a parallel structure, which differs from alpha-chitosan's antiparallel structure while producing different properties and difficulties. In this paper, we prepared the beta-chitosan through acid and alkali methods and the resultant material was characterized by elemental analysis, FT-IR, HPLC, XRD, NMR and AFS. To increase the solubility and biological activity of the beta-chitosan, we degraded it through microwave-assisted process. After characterization, we determined that the chitosan had not changed its configuration during the reaction with H2O2 under microwave irradiation. The inhibitory activity of the degraded chitosan for Newcastle disease was revealed by a hemagglutination test and RT-PCR. The yield of the beta-chitosan was approximately 30%, and its molecular weight can be degraded to 1000 to 10,000 g/mol. Moreover, the degraded p-chitosan has higher antiviral activity, reducing the hemagglutination titre to zero, compared with alpha-chitosan. Therefore, beta-chitosan has good development prospects during the development of veterinary drugs for Newcastle disease. (c) 2015 Elsevier B.V. All rights reserved.
KeywordDegraded Beta-chitosan Microwave-assisted Antiviral Activities For Newcastle Disease
DOI10.1016/j.ijbiomac.2015.10.059
Indexed BySCI
Language英语
WOS IDWOS:000367425100077
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/86656
Collection海洋生物技术研发中心
海洋环境工程技术研究发展中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
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He, Xiaofei,Xing, Ronge,Li, Kecheng,et al. Beta-chitosan extracted from Loligo Japonica for a potential use to inhibit Newcastle disease[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,82(2016):614-620.
APA He, Xiaofei.,Xing, Ronge.,Li, Kecheng.,Qin, Yukun.,Zou, Ping.,...&Li, Pengcheng.(2016).Beta-chitosan extracted from Loligo Japonica for a potential use to inhibit Newcastle disease.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,82(2016),614-620.
MLA He, Xiaofei,et al."Beta-chitosan extracted from Loligo Japonica for a potential use to inhibit Newcastle disease".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 82.2016(2016):614-620.
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