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Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems
Qi, Xin1; Liu, Ge2; Qiu, Lin3; Lin, Xiukun4; Liu, Ming1
2015-10-01
发表期刊BIOMEDICINE & PHARMACOTHERAPY
卷号75期号:2015页码:58-66
文章类型Article
摘要Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol compound derived from marine algae. Our previous reports have shown that BDDE possessed anticancer activity in vitro. However, its antiangiogenesis activity and possible mechanisms remain unclear. The present study demonstrated that BDDE displayed in vitro antiangiogenesis capabilities by significantly inhibiting HUVEC cells proliferation, migration, and tube formation, without any effect on the preformed vascular tube. Western blot analysis revealed that BDDE decreased the protein level of VEGF and VEGFR but not that of EGFR, FGFR, and IGFR. In addition, BDDE inactivated the VEGF downstream signaling molecules including mTOR and Src, whereas activated Akt and ERK. Moreover, BDDE blocked subintestinal vessel formation in zebrafish embryos in vivo and showed toxicity under high concentrations of BDDE. The results of this present study indicated that BDDE, which has unique chemical structure different from current antiangiogenesis agents, could be used as a potential drug candidate for cancer prevention and therapy. (C) 2015 Elsevier Masson SAS. All rights reserved.
关键词Antiangiogenesis Bis(2 Zebrafish 3-dibromo-4 Vegf 5-dihydroxybenzyl) Ether Vegfr
DOI10.1016/j.biopha.2015.08.033
收录类别SCI
语种英语
WOS记录号WOS:000367509300009
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/86651
专题实验海洋生物学重点实验室
作者单位1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
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Qi, Xin,Liu, Ge,Qiu, Lin,et al. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems[J]. BIOMEDICINE & PHARMACOTHERAPY,2015,75(2015):58-66.
APA Qi, Xin,Liu, Ge,Qiu, Lin,Lin, Xiukun,&Liu, Ming.(2015).Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems.BIOMEDICINE & PHARMACOTHERAPY,75(2015),58-66.
MLA Qi, Xin,et al."Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems".BIOMEDICINE & PHARMACOTHERAPY 75.2015(2015):58-66.
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