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Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems
Qi, Xin1; Liu, Ge2; Qiu, Lin3; Lin, Xiukun4; Liu, Ming1
2015-10-01
Source PublicationBIOMEDICINE & PHARMACOTHERAPY
Volume75Issue:2015Pages:58-66
SubtypeArticle
AbstractBis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol compound derived from marine algae. Our previous reports have shown that BDDE possessed anticancer activity in vitro. However, its antiangiogenesis activity and possible mechanisms remain unclear. The present study demonstrated that BDDE displayed in vitro antiangiogenesis capabilities by significantly inhibiting HUVEC cells proliferation, migration, and tube formation, without any effect on the preformed vascular tube. Western blot analysis revealed that BDDE decreased the protein level of VEGF and VEGFR but not that of EGFR, FGFR, and IGFR. In addition, BDDE inactivated the VEGF downstream signaling molecules including mTOR and Src, whereas activated Akt and ERK. Moreover, BDDE blocked subintestinal vessel formation in zebrafish embryos in vivo and showed toxicity under high concentrations of BDDE. The results of this present study indicated that BDDE, which has unique chemical structure different from current antiangiogenesis agents, could be used as a potential drug candidate for cancer prevention and therapy. (C) 2015 Elsevier Masson SAS. All rights reserved.
KeywordAntiangiogenesis Bis(2 Zebrafish 3-dibromo-4 Vegf 5-dihydroxybenzyl) Ether Vegfr
DOI10.1016/j.biopha.2015.08.033
Indexed BySCI
Language英语
WOS IDWOS:000367509300009
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/86651
Collection实验海洋生物学重点实验室
Affiliation1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
4.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
Recommended Citation
GB/T 7714
Qi, Xin,Liu, Ge,Qiu, Lin,et al. Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems[J]. BIOMEDICINE & PHARMACOTHERAPY,2015,75(2015):58-66.
APA Qi, Xin,Liu, Ge,Qiu, Lin,Lin, Xiukun,&Liu, Ming.(2015).Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems.BIOMEDICINE & PHARMACOTHERAPY,75(2015),58-66.
MLA Qi, Xin,et al."Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems".BIOMEDICINE & PHARMACOTHERAPY 75.2015(2015):58-66.
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