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Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis
Hao, Lian-xu1,2,3; Li, Mo-fei1,2,3
2015-12-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号47期号:2页码:717-724
文章类型Article
摘要Chemokines are a large, diverse group of small cytokines that can be classified into several families, including the CC chemokine family, which plays a pivotal role in host defense by inducing leukocyte chemotaxis under physiological and inflammatory conditions. Here we studied 9 CC chemokines from half-smooth tongue sole (Cynoglossus semilaevis). Phylogenetic analysis divided these chemokines into four groups. The tissue specific expression patterns of the 9 chemokines under normal physiological conditions varied much, with most chemokines highly expressed in immune organs, while some other chemokines showing high expression levels in non-immune organs. In addition, the 9 chemokines exhibited similar or distinctly different expression profiles in response to the challenge of virus and intracellular and extracellular bacterial pathogens. These results indicate that in tongue sole, CC chemokines may be involved in different immune responses as homeostatic or inflammatory chemokines. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Cc Chemokine Cynoglossus Semilaevis Antiviral Antibacterial Immune Defense
DOI10.1016/j.fsi.2015.10.003
收录类别SCI
语种英语
WOS记录号WOS:000366874500011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/86637
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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Hao, Lian-xu,Li, Mo-fei. Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(2):717-724.
APA Hao, Lian-xu,&Li, Mo-fei.(2015).Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis.FISH & SHELLFISH IMMUNOLOGY,47(2),717-724.
MLA Hao, Lian-xu,et al."Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis".FISH & SHELLFISH IMMUNOLOGY 47.2(2015):717-724.
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