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Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis
Hao, Lian-xu1,2,3; Li, Mo-fei1,2,3
2015-12-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume47Issue:2Pages:717-724
SubtypeArticle
AbstractChemokines are a large, diverse group of small cytokines that can be classified into several families, including the CC chemokine family, which plays a pivotal role in host defense by inducing leukocyte chemotaxis under physiological and inflammatory conditions. Here we studied 9 CC chemokines from half-smooth tongue sole (Cynoglossus semilaevis). Phylogenetic analysis divided these chemokines into four groups. The tissue specific expression patterns of the 9 chemokines under normal physiological conditions varied much, with most chemokines highly expressed in immune organs, while some other chemokines showing high expression levels in non-immune organs. In addition, the 9 chemokines exhibited similar or distinctly different expression profiles in response to the challenge of virus and intracellular and extracellular bacterial pathogens. These results indicate that in tongue sole, CC chemokines may be involved in different immune responses as homeostatic or inflammatory chemokines. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordCc Chemokine Cynoglossus Semilaevis Antiviral Antibacterial Immune Defense
DOI10.1016/j.fsi.2015.10.003
Indexed BySCI
Language英语
WOS IDWOS:000366874500011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/86637
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hao, Lian-xu,Li, Mo-fei. Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(2):717-724.
APA Hao, Lian-xu,&Li, Mo-fei.(2015).Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis.FISH & SHELLFISH IMMUNOLOGY,47(2),717-724.
MLA Hao, Lian-xu,et al."Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis".FISH & SHELLFISH IMMUNOLOGY 47.2(2015):717-724.
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